Activating transcription factor 3 is a novel repressor of the nuclear factor erythroid-derived 2-related factor 2 (Nrf2)-regulated stress pathway

被引：79

作者：

Brown, Stephan L.

Sekhar, Konjeti R.

Rachakonda, Girish

Sasi, Soumya

Freeman, Michael L. ^{[1
]}

机构：

[1] Vanderbilt Univ, Sch Med, Dept Radiat Oncol, Nashville, TN 37232 USA

来源：

CANCER RESEARCH | 2008年 / 68卷 / 02期

关键词：

D O I：

10.1158/0008-5472.CAN-07-2170

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The transcription factor nuclear factor erythroid-derived 2-related factor 2 (Nrf2) regulates induction of an extensive cellular stress response network when complexed with the cAMP-responsive element binding protein (CBP) at antioxidant response elements (ARE) located in the promoter region of target genes. Activating transcription factor 3 (ATF3) can repress Nrf2-mediated signaling in a manner that is not well understood. Here, we show that ATF3-mediated suppression is a consequence of direct ATF3-Nrf2 protein-protein interactions that result in displacement of CBP from the ARE. This work establishes ATF3 as a novel repressor of the Nrf2-directed stress response pathway.

引用

页码：364 / 368

页数：5

共 20 条

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