Mammalian DNA base excision repair proteins: their interactions and role in repair of oxidative DNA damage

被引：167

作者：

Izumi, T ^{[1
]}

Wiederhold, LR

Roy, G

Roy, R

Jaiswal, A

Bhakat, KK

Mitra, S

Hazra, TK

机构：

[1] Univ Texas, Med Branch, Sealy Ctr Mol Sci, Galveston, TX 77555 USA

[2] Univ Florida, Shands Canc Ctr, Gainesville, FL 32610 USA

[3] Amer Hlth Fdn, Ctr Canc, Div Carcinogenesis & Mol Epidemiol, Valhalla, NY 10595 USA

[4] Acorda Therapeut Inc, Hawthorne, NY 10532 USA

来源：

TOXICOLOGY | 2003年 / 193卷 / 1-2期

关键词：

base excision repair; reactive oxygen species; DNA;

D O I：

10.1016/S0300-483X(03)00289-0

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The DNA base excision repair (BER) is a ubiquitous mechanism for removing damage from the genome induced by spontaneous chemical reaction, reactive oxygen species (ROS) and also DNA damage induced by a variety of environmental genotoxicants. DNA repair is essential for maintaining genomic integrity. As we learn more about BER, a more complex mechanism emerges which supersedes the classical, simple pathway requiring only four enzymatic reactions. The key to understand the complete BER process is to elucidate how multiple proteins interact with one another in a coordinated process under specific physiological conditions. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：43 / 65

页数：23

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