Synthesis and degradation of nucleic acid components by formamide and cosmic dust analogues

被引：68

作者：

Saladino, R

Crestini, C

Neri, V

Brucato, JR

Colangeli, L

Ciciriello, F

Di Mauro, E

Costanzo, G

机构：

[1] Univ Tuscia, Dipartimento ABAC, I-01100 Viterbo, Italy

[2] Univ Roma Tor Vergata, Dipartimento Sci & Tecnol Chim, I-00133 Rome, Italy

[3] INAF Osservat Astron Capodimonte, I-80131 Naples, Italy

[4] CNR, Ist Biol & Patol Mol, I-00185 Rome, Italy

[5] Univ Roma La Sapienza, Dipartimento Genet & Biol Mol, Fdz Ist Pasteur, Fdz Cenci Bolognetti, I-00185 Rome, Italy

来源：

CHEMBIOCHEM | 2005年 / 6卷 / 08期

关键词：

cosmic-dust analogues; nucleic acids; nucleobases; oligonucleotides; pyrimidines;

D O I：

10.1002/cbic.200500035

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We show the unprecedented one-pot synthesis of a large suite of pyrimidines (including cytosine and uracil) and purines from formomide in the presence of cosmic-dust analogues (CDAs) of olivines. Since the major problem in the origin of informational macromolecules is the instability of their precursors, we also investigate the stabilizing effect of CDAs on the intrinsic instability of oligonucleotides in formamide.

引用

页码：1368 / 1374

页数：7

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