共 13 条
Anti-tumor necrosis factor-α antibody limits heart failure in a transgenic model
被引:78
作者:

Kadokami, T
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Med Ctr Hlth Syst, Cardiovasc Inst, Pittsburgh, PA USA

Frye, C
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Med Ctr Hlth Syst, Cardiovasc Inst, Pittsburgh, PA USA

Lemster, B
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Med Ctr Hlth Syst, Cardiovasc Inst, Pittsburgh, PA USA

Wagner, CL
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Med Ctr Hlth Syst, Cardiovasc Inst, Pittsburgh, PA USA

Feldman, AM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Med Ctr Hlth Syst, Cardiovasc Inst, Pittsburgh, PA USA

McTiernan, CF
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Med Ctr Hlth Syst, Cardiovasc Inst, Pittsburgh, PA USA
机构:
[1] Univ Pittsburgh, Med Ctr Hlth Syst, Cardiovasc Inst, Pittsburgh, PA USA
[2] Centocor Inc, Malvern, PA USA
关键词:
antibodies;
heart failure;
hormones;
D O I:
10.1161/hc3501.096063
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Background-Tumor necrosis factor (TNF)-alpha has been implicated in the pathophysiology of congestive heart failure. A strain of transgenic mice (TNF1.6) with cardiac-specific overexpression of TNF-alpha develop congestive heart failure. Methods and Results-To determine the effect of anti-TNF-alpha therapy in this model, we studied 3 groups: TNF1.6 mice treated with saline, wild-type mice treated with saline, and TNF1.6 mice treated with TNF-alpha neutralizing antibody (cV1q) from 6 to 12 weeks of age. We used echocardiography to compare cardiac hypertrophy, function, and catecholamine response at 12 weeks of age versus baseline (6 weeks). cV1q treatment did not limit cardiac hypertrophy, but it significantly improved basal fractional shortening and responsiveness to beta -adrenergic stimulation, and it limited development of cardiac dilation. Conclusions-Blockade of TNF-alpha bioactivity by antibody therapy may both preserve cardiac function and partially reverse pathological changes in congestive heart failure.
引用
收藏
页码:1094 / 1097
页数:4
相关论文
共 13 条
[1]
Results of targeted anti-tumor necrosis factor therapy with etanercept (ENBREL) in patients with advanced heart failure
[J].
Bozkurt, B
;
Torre-Amione, G
;
Warren, MS
;
Whitmore, J
;
Soran, OZ
;
Feldman, AM
;
Mann, DL
.
CIRCULATION,
2001, 103 (08)
:1044-1047

Bozkurt, B
论文数: 0 引用数: 0
h-index: 0
机构: Houston VA Med Ctr, Winters Ctr Heart Failure Res 151C, Dept Med, Houston, TX 77030 USA

Torre-Amione, G
论文数: 0 引用数: 0
h-index: 0
机构: Houston VA Med Ctr, Winters Ctr Heart Failure Res 151C, Dept Med, Houston, TX 77030 USA

Warren, MS
论文数: 0 引用数: 0
h-index: 0
机构: Houston VA Med Ctr, Winters Ctr Heart Failure Res 151C, Dept Med, Houston, TX 77030 USA

Whitmore, J
论文数: 0 引用数: 0
h-index: 0
机构: Houston VA Med Ctr, Winters Ctr Heart Failure Res 151C, Dept Med, Houston, TX 77030 USA

Soran, OZ
论文数: 0 引用数: 0
h-index: 0
机构: Houston VA Med Ctr, Winters Ctr Heart Failure Res 151C, Dept Med, Houston, TX 77030 USA

Feldman, AM
论文数: 0 引用数: 0
h-index: 0
机构: Houston VA Med Ctr, Winters Ctr Heart Failure Res 151C, Dept Med, Houston, TX 77030 USA

Mann, DL
论文数: 0 引用数: 0
h-index: 0
机构: Houston VA Med Ctr, Winters Ctr Heart Failure Res 151C, Dept Med, Houston, TX 77030 USA
[2]
Pathophysiologically relevant concentrations of tumor necrosis factor-α promote progressive left ventricular dysfunction and remodeling in rats
[J].
Bozkurt, B
;
Kribbs, SB
;
Clubb, FJ
;
Michael, LH
;
Didenko, VV
;
Hornsby, PJ
;
Seta, Y
;
Oral, H
;
Spinale, FG
;
Mann, DL
.
CIRCULATION,
1998, 97 (14)
:1382-1391

Bozkurt, B
论文数: 0 引用数: 0
h-index: 0
机构: Vet Adm Med Ctr, Dept Med, Cardiol Sect, Houston, TX 77211 USA

Kribbs, SB
论文数: 0 引用数: 0
h-index: 0
机构: Vet Adm Med Ctr, Dept Med, Cardiol Sect, Houston, TX 77211 USA

Clubb, FJ
论文数: 0 引用数: 0
h-index: 0
机构: Vet Adm Med Ctr, Dept Med, Cardiol Sect, Houston, TX 77211 USA

Michael, LH
论文数: 0 引用数: 0
h-index: 0
机构: Vet Adm Med Ctr, Dept Med, Cardiol Sect, Houston, TX 77211 USA

Didenko, VV
论文数: 0 引用数: 0
h-index: 0
机构: Vet Adm Med Ctr, Dept Med, Cardiol Sect, Houston, TX 77211 USA

Hornsby, PJ
论文数: 0 引用数: 0
h-index: 0
机构: Vet Adm Med Ctr, Dept Med, Cardiol Sect, Houston, TX 77211 USA

Seta, Y
论文数: 0 引用数: 0
h-index: 0
机构: Vet Adm Med Ctr, Dept Med, Cardiol Sect, Houston, TX 77211 USA

Oral, H
论文数: 0 引用数: 0
h-index: 0
机构: Vet Adm Med Ctr, Dept Med, Cardiol Sect, Houston, TX 77211 USA

Spinale, FG
论文数: 0 引用数: 0
h-index: 0
机构: Vet Adm Med Ctr, Dept Med, Cardiol Sect, Houston, TX 77211 USA

Mann, DL
论文数: 0 引用数: 0
h-index: 0
机构: Vet Adm Med Ctr, Dept Med, Cardiol Sect, Houston, TX 77211 USA
[3]
Endoscopic and histological healing with infliximab anti-tumor necrosis factor antibodies in Crohn's disease: A European multicenter trial
[J].
D'Haens, G
;
Van Deventer, S
;
Van Hogezand, R
;
Chalmers, D
;
Kothe, C
;
Baert, F
;
Braakman, T
;
Schaible, T
;
Geboes, K
;
Rutgeerts, P
.
GASTROENTEROLOGY,
1999, 116 (05)
:1029-1034

D'Haens, G
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hosp Gasthuisberg, Dept Gastroenterol, B-3000 Louvain, Belgium

Van Deventer, S
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hosp Gasthuisberg, Dept Gastroenterol, B-3000 Louvain, Belgium

Van Hogezand, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hosp Gasthuisberg, Dept Gastroenterol, B-3000 Louvain, Belgium

Chalmers, D
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hosp Gasthuisberg, Dept Gastroenterol, B-3000 Louvain, Belgium

Kothe, C
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hosp Gasthuisberg, Dept Gastroenterol, B-3000 Louvain, Belgium

Baert, F
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hosp Gasthuisberg, Dept Gastroenterol, B-3000 Louvain, Belgium

Braakman, T
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hosp Gasthuisberg, Dept Gastroenterol, B-3000 Louvain, Belgium

Schaible, T
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hosp Gasthuisberg, Dept Gastroenterol, B-3000 Louvain, Belgium

Geboes, K
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hosp Gasthuisberg, Dept Gastroenterol, B-3000 Louvain, Belgium

Rutgeerts, P
论文数: 0 引用数: 0
h-index: 0
机构: Univ Hosp Gasthuisberg, Dept Gastroenterol, B-3000 Louvain, Belgium
[4]
RANDOMIZED DOUBLE-BLIND COMPARISON OF CHIMERIC MONOCLONAL-ANTIBODY TO TUMOR-NECROSIS-FACTOR-ALPHA (CA2) VERSUS PLACEBO IN RHEUMATOID-ARTHRITIS
[J].
ELLIOTT, MJ
;
MAINI, RN
;
FELDMANN, M
;
KALDEN, JR
;
ANTONI, C
;
SMOLEN, JS
;
LEEB, B
;
BREEDVELD, FC
;
MACFARLANE, JD
;
BIJL, H
;
WOODY, JN
.
LANCET,
1994, 344 (8930)
:1105-1110

ELLIOTT, MJ
论文数: 0 引用数: 0
h-index: 0
机构: KENNEDY INST,LONDON W6 7DW,ENGLAND

MAINI, RN
论文数: 0 引用数: 0
h-index: 0
机构: KENNEDY INST,LONDON W6 7DW,ENGLAND

FELDMANN, M
论文数: 0 引用数: 0
h-index: 0
机构: KENNEDY INST,LONDON W6 7DW,ENGLAND

KALDEN, JR
论文数: 0 引用数: 0
h-index: 0
机构: KENNEDY INST,LONDON W6 7DW,ENGLAND

ANTONI, C
论文数: 0 引用数: 0
h-index: 0
机构: KENNEDY INST,LONDON W6 7DW,ENGLAND

SMOLEN, JS
论文数: 0 引用数: 0
h-index: 0
机构: KENNEDY INST,LONDON W6 7DW,ENGLAND

LEEB, B
论文数: 0 引用数: 0
h-index: 0
机构: KENNEDY INST,LONDON W6 7DW,ENGLAND

BREEDVELD, FC
论文数: 0 引用数: 0
h-index: 0
机构: KENNEDY INST,LONDON W6 7DW,ENGLAND

MACFARLANE, JD
论文数: 0 引用数: 0
h-index: 0
机构: KENNEDY INST,LONDON W6 7DW,ENGLAND

BIJL, H
论文数: 0 引用数: 0
h-index: 0
机构: KENNEDY INST,LONDON W6 7DW,ENGLAND

WOODY, JN
论文数: 0 引用数: 0
h-index: 0
机构: KENNEDY INST,LONDON W6 7DW,ENGLAND
[5]
Sex-related survival differences in murine cardiomyopathy are associated with differences in TNF-receptor expression
[J].
Kadokami, T
;
McTiernan, CF
;
Kubota, T
;
Frye, CS
;
Feldman, AM
.
JOURNAL OF CLINICAL INVESTIGATION,
2000, 106 (04)
:589-597

Kadokami, T
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Cardiovasc Inst, Med Ctr, Hlth Syst, Pittsburgh, PA 15213 USA Univ Pittsburgh, Cardiovasc Inst, Med Ctr, Hlth Syst, Pittsburgh, PA 15213 USA

McTiernan, CF
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Cardiovasc Inst, Med Ctr, Hlth Syst, Pittsburgh, PA 15213 USA Univ Pittsburgh, Cardiovasc Inst, Med Ctr, Hlth Syst, Pittsburgh, PA 15213 USA

Kubota, T
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Cardiovasc Inst, Med Ctr, Hlth Syst, Pittsburgh, PA 15213 USA Univ Pittsburgh, Cardiovasc Inst, Med Ctr, Hlth Syst, Pittsburgh, PA 15213 USA

Frye, CS
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Cardiovasc Inst, Med Ctr, Hlth Syst, Pittsburgh, PA 15213 USA Univ Pittsburgh, Cardiovasc Inst, Med Ctr, Hlth Syst, Pittsburgh, PA 15213 USA

Feldman, AM
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Cardiovasc Inst, Med Ctr, Hlth Syst, Pittsburgh, PA 15213 USA Univ Pittsburgh, Cardiovasc Inst, Med Ctr, Hlth Syst, Pittsburgh, PA 15213 USA
[6]
Soluble tumor necrosis factor receptor abrogates myocardial inflammation but not hypertrophy in cytokine-induced cardiomyopathy
[J].
Kubota, T
;
Bounoutas, GS
;
Miyagishima, M
;
Kadokami, T
;
Sanders, VJ
;
Bruton, C
;
Robbins, PD
;
McTiernan, CF
;
Feldman, AM
.
CIRCULATION,
2000, 101 (21)
:2518-2525

Kubota, T
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Med Ctr, Cardiovasc Inst, Pittsburgh, PA USA

Bounoutas, GS
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Med Ctr, Cardiovasc Inst, Pittsburgh, PA USA

Miyagishima, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Med Ctr, Cardiovasc Inst, Pittsburgh, PA USA

Kadokami, T
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Med Ctr, Cardiovasc Inst, Pittsburgh, PA USA

Sanders, VJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Med Ctr, Cardiovasc Inst, Pittsburgh, PA USA

Bruton, C
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Med Ctr, Cardiovasc Inst, Pittsburgh, PA USA

Robbins, PD
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Med Ctr, Cardiovasc Inst, Pittsburgh, PA USA

McTiernan, CF
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Med Ctr, Cardiovasc Inst, Pittsburgh, PA USA

Feldman, AM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Med Ctr, Cardiovasc Inst, Pittsburgh, PA USA
[7]
Dilated cardiomyopathy in transgenic mice with cardiac-specific overexpression of tumor necrosis factor-alpha
[J].
Kubota, T
;
McTiernan, CF
;
Frye, CS
;
Slawson, SE
;
Lemster, BH
;
Koretsky, AP
;
Demetris, AJ
;
Feldman, AM
.
CIRCULATION RESEARCH,
1997, 81 (04)
:627-635

Kubota, T
论文数: 0 引用数: 0
h-index: 0
机构: UNIV PITTSBURGH, MED CTR, DIV CARDIOL, CARDIOVASC RES LABS, PITTSBURGH, PA 15213 USA

McTiernan, CF
论文数: 0 引用数: 0
h-index: 0
机构: UNIV PITTSBURGH, MED CTR, DIV CARDIOL, CARDIOVASC RES LABS, PITTSBURGH, PA 15213 USA

Frye, CS
论文数: 0 引用数: 0
h-index: 0
机构: UNIV PITTSBURGH, MED CTR, DIV CARDIOL, CARDIOVASC RES LABS, PITTSBURGH, PA 15213 USA

Slawson, SE
论文数: 0 引用数: 0
h-index: 0
机构: UNIV PITTSBURGH, MED CTR, DIV CARDIOL, CARDIOVASC RES LABS, PITTSBURGH, PA 15213 USA

Lemster, BH
论文数: 0 引用数: 0
h-index: 0
机构: UNIV PITTSBURGH, MED CTR, DIV CARDIOL, CARDIOVASC RES LABS, PITTSBURGH, PA 15213 USA

Koretsky, AP
论文数: 0 引用数: 0
h-index: 0
机构: UNIV PITTSBURGH, MED CTR, DIV CARDIOL, CARDIOVASC RES LABS, PITTSBURGH, PA 15213 USA

Demetris, AJ
论文数: 0 引用数: 0
h-index: 0
机构: UNIV PITTSBURGH, MED CTR, DIV CARDIOL, CARDIOVASC RES LABS, PITTSBURGH, PA 15213 USA

Feldman, AM
论文数: 0 引用数: 0
h-index: 0
机构: UNIV PITTSBURGH, MED CTR, DIV CARDIOL, CARDIOVASC RES LABS, PITTSBURGH, PA 15213 USA
[8]
ELEVATED CIRCULATING LEVELS OF TUMOR-NECROSIS-FACTOR IN SEVERE CHRONIC HEART-FAILURE
[J].
LEVINE, B
;
KALMAN, J
;
MAYER, L
;
FILLIT, HM
;
PACKER, M
.
NEW ENGLAND JOURNAL OF MEDICINE,
1990, 323 (04)
:236-241

LEVINE, B
论文数: 0 引用数: 0
h-index: 0
机构: CUNY MT SINAI SCH MED,DIV CARDIOL,1 GUSTAVE LEVY PL,NEW YORK,NY 10029

KALMAN, J
论文数: 0 引用数: 0
h-index: 0
机构: CUNY MT SINAI SCH MED,DIV CARDIOL,1 GUSTAVE LEVY PL,NEW YORK,NY 10029

MAYER, L
论文数: 0 引用数: 0
h-index: 0
机构: CUNY MT SINAI SCH MED,DIV CARDIOL,1 GUSTAVE LEVY PL,NEW YORK,NY 10029

FILLIT, HM
论文数: 0 引用数: 0
h-index: 0
机构: CUNY MT SINAI SCH MED,DIV CARDIOL,1 GUSTAVE LEVY PL,NEW YORK,NY 10029

PACKER, M
论文数: 0 引用数: 0
h-index: 0
机构: CUNY MT SINAI SCH MED,DIV CARDIOL,1 GUSTAVE LEVY PL,NEW YORK,NY 10029
[9]
Myocardial extracellular matrix remodeling in transgenic mice overexpressing tumor necrosis factor α can be modulated by anti-tumor necrosis factor α therapy
[J].
Li, YY
;
Feng, YQ
;
Kadokami, T
;
McTiernan, CF
;
Draviam, R
;
Watkins, SC
;
Feldman, AM
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
2000, 97 (23)
:12746-12751

Li, YY
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Sch Med, Cardiovasc Inst, Pittsburgh, PA 15213 USA

Feng, YQ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Sch Med, Cardiovasc Inst, Pittsburgh, PA 15213 USA

Kadokami, T
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Sch Med, Cardiovasc Inst, Pittsburgh, PA 15213 USA

McTiernan, CF
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Sch Med, Cardiovasc Inst, Pittsburgh, PA 15213 USA

Draviam, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Sch Med, Cardiovasc Inst, Pittsburgh, PA 15213 USA

Watkins, SC
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Sch Med, Cardiovasc Inst, Pittsburgh, PA 15213 USA

Feldman, AM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Sch Med, Cardiovasc Inst, Pittsburgh, PA 15213 USA
[10]
Treatment of rheumatoid arthritis with a recombinant human tumor necrosis factor receptor (p75)-Fc fusion protein
[J].
Moreland, LW
;
Baumgartner, SW
;
Schiff, MH
;
Tindall, EA
;
Fleischmann, RM
;
Weaver, AL
;
Ettlinger, RE
;
Cohen, S
;
Koopman, WJ
;
Mohler, K
;
Widmer, MB
;
Blosch, CM
.
NEW ENGLAND JOURNAL OF MEDICINE,
1997, 337 (03)
:141-147

Moreland, LW
论文数: 0 引用数: 0
h-index: 0
机构: PHYSICIANS CLIN SPOKANE,SPOKANE,WA

Baumgartner, SW
论文数: 0 引用数: 0
h-index: 0
机构: PHYSICIANS CLIN SPOKANE,SPOKANE,WA

Schiff, MH
论文数: 0 引用数: 0
h-index: 0
机构: PHYSICIANS CLIN SPOKANE,SPOKANE,WA

Tindall, EA
论文数: 0 引用数: 0
h-index: 0
机构: PHYSICIANS CLIN SPOKANE,SPOKANE,WA

Fleischmann, RM
论文数: 0 引用数: 0
h-index: 0
机构: PHYSICIANS CLIN SPOKANE,SPOKANE,WA

Weaver, AL
论文数: 0 引用数: 0
h-index: 0
机构: PHYSICIANS CLIN SPOKANE,SPOKANE,WA

Ettlinger, RE
论文数: 0 引用数: 0
h-index: 0
机构: PHYSICIANS CLIN SPOKANE,SPOKANE,WA

Cohen, S
论文数: 0 引用数: 0
h-index: 0
机构: PHYSICIANS CLIN SPOKANE,SPOKANE,WA

Koopman, WJ
论文数: 0 引用数: 0
h-index: 0
机构: PHYSICIANS CLIN SPOKANE,SPOKANE,WA

Mohler, K
论文数: 0 引用数: 0
h-index: 0
机构: PHYSICIANS CLIN SPOKANE,SPOKANE,WA

Widmer, MB
论文数: 0 引用数: 0
h-index: 0
机构: PHYSICIANS CLIN SPOKANE,SPOKANE,WA

Blosch, CM
论文数: 0 引用数: 0
h-index: 0
机构: PHYSICIANS CLIN SPOKANE,SPOKANE,WA