BIRB-796 is not an effective ABL(T315I) inhibitor

被引:20
作者
O'Hare, T [1 ]
Druker, BJ [1 ]
机构
[1] Oregon Hlth & Sci Univ, Howard Hughes Med Inst, Inst Canc, Portland, OR 97239 USA
关键词
D O I
10.1038/nbt1005-1209
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
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页码:1209 / 1210
页数:2
相关论文
共 8 条
[1]   A small molecule-kinase interaction map for clinical kinase inhibitors [J].
Fabian, MA ;
Biggs, WH ;
Treiber, DK ;
Atteridge, CE ;
Azimioara, MD ;
Benedetti, MG ;
Carter, TA ;
Ciceri, P ;
Edeen, PT ;
Floyd, M ;
Ford, JM ;
Galvin, M ;
Gerlach, JL ;
Grotzfeld, RM ;
Herrgard, S ;
Insko, DE ;
Insko, MA ;
Lai, AG ;
Lélias, JM ;
Mehta, SA ;
Milanov, ZV ;
Velasco, AM ;
Wodicka, LM ;
Patel, HK ;
Zarrinkar, PP ;
Lockhart, DJ .
NATURE BIOTECHNOLOGY, 2005, 23 (03) :329-336
[2]  
Nagar B, 2002, CANCER RES, V62, P4236
[3]   In vitro activity of Bcr-Abl inhibitors AMN107 and BMS-354825 against clinically relevant imatinib-resistant Abl kinase domain mutants [J].
O'Hare, T ;
Walters, DK ;
Stoffregen, EP ;
Jia, TP ;
Manley, PW ;
Mestan, J ;
Cowan-Jacob, SW ;
Lee, FY ;
Heinrich, MC ;
Deininger, MWN ;
Druker, BJ .
CANCER RESEARCH, 2005, 65 (11) :4500-4505
[4]   AMN107: Tightening the grip of imatinib [J].
O'Hare, T ;
Walters, DK ;
Deininger, MWN ;
Druker, BJ .
CANCER CELL, 2005, 7 (02) :117-119
[5]   Inhibition of wild-type and mutant Bcr-Abl by AP23464, a potent ATP-based oncogenic protein kinase inhibitor: implications for CML [J].
O'Hare, T ;
Pollock, R ;
Stoffregen, EP ;
Keats, JA ;
Abdullah, OM ;
Moseson, EM ;
Rivera, VM ;
Tang, H ;
Metcalf, CA ;
Bohacek, RS ;
Wang, YH ;
Sundaramoorthi, R ;
Shakespeare, WC ;
Dalgarno, D ;
Clackson, T ;
Sawyer, TK ;
Deininger, MW ;
Druker, BJ .
BLOOD, 2004, 104 (08) :2532-2539
[6]   Imatinib inhibits T-cell receptor-mediated T-cell proliferation and activation in a dose-dependent manner [J].
Seggewiss, R ;
Loré, K ;
Greiner, E ;
Magnusson, MK ;
Price, DA ;
Douek, DC ;
Dunbar, CE ;
Wiestner, A .
BLOOD, 2005, 105 (06) :2473-2479
[7]   Overriding imatinib resistance with a novel ABL kinase inhibitor [J].
Shah, NP ;
Tran, C ;
Lee, FY ;
Chen, P ;
Norris, D ;
Sawyers, CL .
SCIENCE, 2004, 305 (5682) :399-401
[8]   Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl [J].
Weisberg, E ;
Manley, PW ;
Breitenstein, W ;
Brüggen, J ;
Cowan-Jacob, SW ;
Ray, A ;
Huntly, B ;
Fabbro, D ;
Fendrich, G ;
Hall-Meyers, E ;
Kung, AL ;
Mestan, J ;
Daley, GQ ;
Callahan, L ;
Catley, L ;
Cavazza, C ;
Mohammed, A ;
Neuberg, D ;
Wright, RD ;
Gilliland, DG ;
Griffin, JD .
CANCER CELL, 2005, 7 (02) :129-141