Extensive axonal Lewy neurites in Parkinson's disease:: a novel pathological feature revealed by α-synuclein immunocytochemistry

被引：210

作者：

Braak, H

Sandmann-Keil, D

Gai, WP

Braak, E

机构：

[1] JW Goethe Univ, Dept Anat, D-60590 Frankfurt, Germany

[2] Flinders Univ S Australia, Med Ctr, Dept Physiol, Bedford Pk, SA 5042, Australia

来源：

NEUROSCIENCE LETTERS | 1999年 / 265卷 / 01期

基金：

英国医学研究理事会;

关键词：

Lewy neurites; Lewy bodies; Parkinson's disease; immunocytochemistry; alpha-synuclein;

D O I：

10.1016/S0304-3940(99)00208-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Lewy bodies and coarse Lewy neu rites are the pathological hallmarks of degenerating neurons in the brains of patients suffering from Parkinson's disease (PD). Recently, the presynaptic protein alpha-synuclein was shown to be a major component of Lewy bodies and Lewy neurites. This study demonstrates for the first time that extensive and thin alpha-synuclein-immunoreactive inclusions a re present in the axonal processes of neurons. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：67 / 69

页数：3

共 16 条

[1]

Baba M, 1998, AM J PATHOL, V152, P879

[2] Pattern of brain destruction in Parkinson's and Alzheimer's diseases [J].