Recent Advances of Cell-Cycle Inhibitor Therapies for Pediatric Cancer

被引：62

作者：

Mills, Christopher C. ^{[1
]}

Kolb, E. A. ^{[2
]}

Sampson, Valerie B. ^{[2
]}

机构：

[1] Univ Delaware, Newark, DE USA

[2] Nemours Alfred I duPont Hosp Children, Nemours Ctr Canc & Blood Disorders, Wilmington, DE USA

来源：

CANCER RESEARCH | 2017年 / 77卷 / 23期

关键词：

CHILDRENS ONCOLOGY GROUP; PHASE-I TRIAL; REFRACTORY SOLID TUMORS; ACUTE LYMPHOBLASTIC-LEUKEMIA; DEPENDENT KINASE INHIBITOR; SMALL-MOLECULE INHIBITOR; ACUTE MYELOID-LEUKEMIA; PRECLINICAL TESTING PROGRAM; AURORA-KINASE; CDK4/6; INHIBITOR;

D O I：

10.1158/0008-5472.CAN-17-2066

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

This review describes the pivotal roles of cell-cycle and checkpoint regulators and discusses development of specific cell-cycle inhibitors for therapeutic use for pediatric cancer. The mechanism of action as well as the safety and tolerability of drugs in pediatric patients, including compounds that target CDK4/CDK6 (palbociclib, ribociclib, and abemaciclib), aurora kinases (AT9283 and MLN8237), Wee1 kinase (MK-1775), KSP (ispinesib), and tubulin (taxanes, vinca alkaloids), are presented. The design of mechanism-based combinations that exploit the cross-talk of signals activated by cell-cycle arrest, as well as pediatric-focused drug development, are critical for the advancement of drugs for rare childhood diseases. (C) 2017 AACR.

引用

收藏

页码：6489 / 6498

页数：10

相关论文

共 84 条

[1]

PD-0332991, a CDK4/6 Inhibitor, Significantly Prolongs Survival in a Genetically Engineered Mouse Model of Brainstem Glioma [J].

Barton, Kelly L. ;

Misuraca, Katherine ;

Cordero, Francisco ;

Dobrikova, Elena ;

Min, Hooney D. ;

Gromeier, Matthias ;

Kirsch, David G. ;

Becher, Oren J. .

PLOS ONE, 2013, 8 (10)

[2]

Cell cycle, cytoskeleton dynamics and beyond: the many functions of cyclins and CDK inhibitors [J].

Bendris, Nawal ;

Lemmers, Benedicte ;

Blanchard, Jean Marie .

CELL CYCLE, 2015, 14 (12) :1786-1796

[3]

A phase I trial of ispinesib, a kinesin spindle protein inhibitor, with docetaxel in patients with advanced solid tumours [J].

Blagden, S. P. ;

Molife, L. R. ;

Seebaran, A. ;

Payne, M. ;

Reid, A. H. M. ;

Protheroe, A. S. ;

Vasist, L. S. ;

Williams, D. D. ;

Bowen, C. ;

Kathman, S. J. ;

Hodge, J. P. ;

Dar, M. M. ;

de Bono, J. S. ;

Middleton, M. R. .

BRITISH JOURNAL OF CANCER, 2008, 98 (05) :894-899

[4]

Phase I trial of docetaxel administered as a 1-hour infusion in children with refractory solid tumors: A collaborative Pediatric Branch, National Cancer Institute and Children's Cancer Group trial [J].

Blaney, SM ;

Seibel, NL ;

OBrien, M ;

Reaman, GH ;

Berg, SL ;

Adamson, PC ;

Poplack, DG ;

Krailo, MD ;

Mosher, R ;

Balis, FM .

JOURNAL OF CLINICAL ONCOLOGY, 1997, 15 (04) :1538-1543

[5]

Myc and cell cycle control [J].

Bretones, Gabriel ;

Dolores Delgado, M. ;

Leon, Javier .

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS, 2015, 1849 (05) :506-516

[6]

Calvo E C, 2005, PHILADELPHIA

[7]

Treatment of Hodgkin Lymphoma: A 50-Year Perspective [J].

Canellos, George P. ;

Rosenberg, Saul A. ;

Friedberg, Jonathan W. ;

Lister, T. Andrew ;

DeVita, Vincent T. .

JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (03) :163-+

[8]

WEE1 Kinase Inhibition Enhances the Radiation Response of Diffuse Intrinsic Pontine Gliomas [J].

Caretti, Viola ;

Hiddingh, Lotte ;

Lagerweij, Tonny ;

Schellen, Pepijn ;

Koken, Phil W. ;

Hulleman, Esther ;

van Vuurden, Dannis G. ;

Vandertop, W. Peter ;

Kaspers, Gertjan J. L. ;

Noske, David P. ;

Wurdinger, Thomas .

MOLECULAR CANCER THERAPEUTICS, 2013, 12 (02) :141-150

[9]

Initial Testing (Stage 1) of the Kinesin Spindle Protein Inhibitor Ispinesib by the Pediatric Preclinical Testing Program [J].

Carol, Hernan ;

Lock, Richard ;

Houghton, Peter J. ;

Morton, Christopher L. ;

Kolb, E. Anders ;

Gorlick, Richard ;

Reynolds, C. Patrick ;

Maris, John M. ;

Keir, Stephen T. ;

Billups, Catherine A. ;

Smith, Malcolm A. .

PEDIATRIC BLOOD & CANCER, 2009, 53 (07) :1255-1263

[10]

Hitting the brakes: targeting microtubule motors in cancer [J].

Chandrasekaran, Gayathri ;

Tatrai, Peter ;

Gergely, Fanni .

BRITISH JOURNAL OF CANCER, 2015, 113 (05) :693-698

← 1 2 3 4 5 6 7 8 9 →