Mammalian iron transport: An unexpected link between metal homeostasis and host defense

被引：32

作者：

Fleming, MD

Andrews, NC

机构：

[1] Childrens Hosp, Howard Hughes Med Inst, Div Hematol Oncol, Boston, MA 02115 USA

[2] Brigham & Womens Hosp, Dept Pathol, Boston, MA 02115 USA

[3] Howard Hughes Med Inst, Boston, MA USA

[4] Harvard Med Sch, Dept Pediat, Boston, MA USA

来源：

JOURNAL OF LABORATORY AND CLINICAL MEDICINE | 1998年 / 132卷 / 06期

关键词：

D O I：

10.1016/S0022-2143(98)90123-8

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Iron deficiency and iron overload disorders are common in clinical practice, Both can result from perturbations in the flux of iron across the absorptive intestinal enterocyte, Until recently iron transport has been poorly understood. In 1997 two independent cloning strategies identified Nramp2 (DCT1) as the first mammalian transmembrane iron transporter. In this review we discuss evidence that Nramp-related proteins play essential roles in metal homeostasis and host defense.

引用

页码：464 / 468

页数：5

共 33 条

[1] Susceptibility to leprosy is linked to the human NRAMP1 gene [J].