Direct asymmetric aldol reactions of acetone using bimetallic zinc catalysts

被引：164

作者：

Trost, BM ^{[1
]}

Silcoff, ER ^{[1
]}

Ito, H ^{[1
]}

机构：

[1] Stanford Univ, Dept Chem, Stanford, CA 94305 USA

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 16期

关键词：

D O I：

10.1021/ol0161211

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The enantioselective aldol reaction using a novel binuclear zinc catalyst of acetone with several aldehydes gave products in good yields (62-89%) with a high level of enantioselectivity (ee = 76-92%).

引用

页码：2497 / 2500

页数：4

共 30 条

[1] [Anonymous], 1994, Org. React
[2] [Anonymous], 1997, ORG REACT
[3] BERTZ SH, 1980, SYNTHESIS-STUTTGART, P708
[4] CATALYTIC, ENANTIOSELECTIVE ACETONE ALDOL ADDITIONS WITH 2-METHOXYPROPENE
CARREIRA, EM
LEE, W
SINGER, RA
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (12) : 3649 - 3650
[5] CARREIRA I, 1999, COMPREHENSIVE ASYMME, V3, P998
[6] Synthesis of chiral C2-symmetric binucleating ligands
Fahrni, CJ
Pfaltz, A
[J]. HELVETICA CHIMICA ACTA, 1998, 81 (03) : 491 - 506
[7] FITZGERALD JS, 1995, J APPL CHEM-USSR, P289
[8] KNOEVENAGEL REACTIONS WITH BETA-OXO ACIDS - REGIOSPECIFIC ENOL EQUIVALENTS FOR SYNTHESES OF ALPHA,BETA-UNSATURATED KETONES AND OF SOME BETA-KETOLS
GRAYSON, DH
TUITE, MRJ
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1986, (12): : 2137 - 2142
[9] Groger H, 1998, CHEM-EUR J, V4, P1137
[10] Heathcock CH., 1991, Comprehensive Organic Synthesis, V2

← 1 2 3 →