Ig heavy-chain gene revision: leaping towards autoimmunity

被引：18

作者：

Klonowski, KD ^{[1
]}

Monestier, M ^{[1
]}

机构：

[1] Temple Univ, Sch Med, Dept Microbiol & Immunol, Philadelphia, PA 19140 USA

来源：

TRENDS IN IMMUNOLOGY | 2001年 / 22卷 / 07期

关键词：

D O I：

10.1016/S1471-4906(01)01953-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

B cells can revise their antigen receptors outside the confines of the bone marrow by secondary Ig gene rearrangements. Although the initial motivation to perform these revisions might be to silence a self-reactive specificity, those B cells that reinitiate the recombination process can perform a series of 'leaping' rearrangements and inadvertently shift their receptor specificity towards autoimmunity. Heavy-chain receptor revision, coupled with other atypical rearrangements, might contribute to autoantibody production in systemic lupus erythematosus.

引用

页码：400 / 405

页数：6

共 62 条

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