Compressibility and compactibility of granules produced by wet and dry granulation

被引：57

作者：

Bacher, C. ^{[1
]}

Olsen, P. M. ^{[2
]}

Bertelsen, P. ^{[2
]}

Sonnergaard, J. M. ^{[1
]}

机构：

[1] Univ Copenhagen, Fac Pharmaceut Sci, Dept Pharmaceut Analyt Chem, DK-2100 Copenhagen, Denmark

[2] Nycomed, Pharmaceut Dev, DK-4000 Roskilde, Denmark

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2008年 / 358卷 / 1-2期

关键词：

roller compaction; granulation; compressibility; compactibility; morphology; particle size;

D O I：

10.1016/j.ijpharm.2008.02.013

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The bulk properties, compactibility and compressibility of granules produced by wet and dry granulation were compared applying a rotary tablet press, three different morphological forms of calcium carbonate and two particle sizes of sorbitol. Granules from both granulation methods possessed acceptable flow properties; however, the ground (Mikhart) and cubic (Scoralite) calcium carbonate demonstrated better die-filling abilities in the tablet press than the scalenhedral calcium carbonate (Sturcal). The wet processed granules showed in general larger compression properties. This was explained as these granules were mechanical stronger and had a higher initial porosity. In some cases, a large particle surface area of calcium carbonate and sorbitol resulted in a small, insignificant improvement of the consolidation characteristics. A correlation between the compression and compaction characteristics was demonstrated. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：69 / 74

页数：6

共 19 条

[1]

ALDERBORN G, 1996, PARTICLE DIMENSIONS, V71, P256

[2] Granule fraction inhomogeneity of calcium carbonate/sorbitol in roller compacted granules [J].

Bacher, C. ;

Olsen, P. M. ;

Bertelsen, P. ;

Sonnergaard, J. M. .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2008, 349 (1-2) :19-23

[3] Improving the compaction properties of roller compacted calcium carbonate [J].

Bacher, C. ;

Olsen, P. M. ;

Bertelsen, P. ;

Kristensen, J. ;

Sonnergaard, J. M. .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2007, 342 (1-2) :115-123

[4]

Carr R.L., 1965, Chem. Eng, V72, P163, DOI DOI 10.1016/J.JAEROSCI.2007.10.003

[5]

*COUNC EUR, 2005, EUR PHARM 2 9 15 APP, P241

[6]

Draper N., 2014, Applied Regression Analysis

[7] How do roll compaction/dry granulation affect the tableting behaviour of inorganic materials? Microhardness of ribbons and mercury porosimetry measurements of tablets [J].

Freitag, F ;

Reincke, K ;

Runge, J ;

Grellmann, W ;

Kleinebudde, P .

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2004, 22 (04) :325-333

[8] How do roll compaction/dry granulation affect the tableting behaviour of inorganic materials? Comparison of four magnesium carbonates [J].

Freitag, F ;

Kleinebudde, P .

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2003, 19 (04) :281-289

[9]

HALD A, 1957, COMPARISON TWO REGRE, P571

[10]

HARSAAE E, 1966, MIDDELTAL S2 VAERDIE, P102

← 1 2 →