Maintenance of presynaptic function by AMPA receptor-mediated excitatory postsynaptic activity in adult brain

被引：47

作者：

Kakizawa, S

Miyazaki, T

Yanagihara, D

Iino, M

Watanabe, M

Kano, M ^{[1
]}

机构：

[1] Kanazawa Univ, Grad Sch Med Sci, Dept Cellular Neurophysiol, Kanazawa, Ishikawa 9208640, Japan

[2] Univ Tokyo, Grad Sch Med, Dept Pharmacol, Tokyo 1130033, Japan

[3] Hokkaido Univ, Sch Med, Dept Anat, Sapporo, Hokkaido 0608638, Japan

[4] Univ Tokyo, Grad Sch Arts & Sci, Dept Life Sci, Tokyo 1538902, Japan

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2005年 / 102卷 / 52期

关键词：

adult mouse; cerebellar Purkinje cell; climbing fiber; neuronal activity; presynaptic function;

D O I：

10.1073/pnas.0504359103

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Activity-dependent synaptic modification occurs in both developing and mature animals. For reliable information transfer and storage, however, once established, synapses must be maintained stably. We investigated how chronic blockade of neuronal activity or alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors affects excitatory climbing fiber (CF) to Purkinje cell (PC) synapses in adult mouse cerebellum. Both treatments caused reduced glutamate concentration transient at the synaptic cleft, decreased frequency of quantal excitatory postsynaptic current, and diminished CF innervation of PC shaft dendrites but no change in CF's release probability. These results indicate that, in the mature cerebellum, AMPA receptor-mediated excitatory postsynaptic activity maintains CF's functional glutamate-release sites and its innervation of PC shaft dendrites.

引用

页码：19180 / 19185

页数：6

共 43 条

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