Depression, antidepressants, and the shrinking hippocampus

被引:246
作者
Sapolsky, RM
机构
[1] Stanford Univ, Dept Biol Sci, Stanford, CA 94305 USA
[2] Stanford Univ, Sch Med, Dept Neurol, Gilbert Lab, Stanford, CA 94305 USA
关键词
D O I
10.1073/pnas.231475998
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
引用
收藏
页码:12320 / 12322
页数:3
相关论文
共 25 条
[1]   Hippocampal volume reduction in major depression [J].
Bremner, JD ;
Narayan, M ;
Anderson, ER ;
Staib, LH ;
Miller, HL ;
Charney, DS .
AMERICAN JOURNAL OF PSYCHIATRY, 2000, 157 (01) :115-117
[2]   Depletion in serotonin decreases neurogenesis in the dentate gyrus and the subventricular zone of adult rats [J].
Brezun, JM ;
Daszuta, A .
NEUROSCIENCE, 1999, 89 (04) :999-1002
[3]   Serotonin may stimulate granule cell proliferation in the adult hippocampus, as observed in rats grafted with foetal raphe neurons [J].
Brezun, JM ;
Daszuta, A .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2000, 12 (01) :391-396
[4]   Enhancement of hippocampal neurogenesis by lithium [J].
Chen, G ;
Rajkowska, G ;
Du, F ;
Seraji-Bozorgzad, N ;
Manji, HK .
JOURNAL OF NEUROCHEMISTRY, 2000, 75 (04) :1729-1734
[5]   Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine [J].
Czéh, B ;
Michaelis, T ;
Watanabe, T ;
Frahm, J ;
de Biurrun, G ;
van Kampen, M ;
Bartolomucci, A ;
Fuchs, E .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (22) :12796-12801
[6]   Psychosocial stress in tree shrews: Clomipramine counteracts behavioral and endocrine changes [J].
Fuchs, E ;
Kramer, M ;
Hermes, B ;
Netter, P ;
Hiemke, C .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1996, 54 (01) :219-228
[7]   Learning enhances adult neurogenesis in the hippocampal formation [J].
Gould, E ;
Beylin, A ;
Tanapat, P ;
Reeves, A ;
Shors, TJ .
NATURE NEUROSCIENCE, 1999, 2 (03) :260-265
[8]  
Gould E, 1997, J NEUROSCI, V17, P2492
[9]   Antidepressants and hypothalamic pituitary adrenocortical regulation [J].
Holsboer, F ;
Barden, N .
ENDOCRINE REVIEWS, 1996, 17 (02) :187-205
[10]  
Holsboer Florian, 1995, P957