Field defects in progression to gastrointestinal tract cancers

被引：51

作者：

Bernstein, Carol ^{[1
,4
]}

Bernstein, Harris ^{[1
,3
]}

Payne, Claire M. ^{[1
,3
]}

Dvorak, Katerina ^{[1
,3
,4
]}

Garewal, Harinder ^{[2
,3
,4
]}

机构：

[1] Univ Arizona, Coll Med, Dept Cell Biol & Anat, Tucson, AZ 85724 USA

[2] Univ Arizona, Dept Internal Med, Tucson, AZ 85724 USA

[3] Univ Arizona, Arizona Canc Ctr, Tucson, AZ 85724 USA

[4] Hematol Oncol So Arizona Vet Affairs Hlth Care Sy, Tucson, AZ 85723 USA

来源：

CANCER LETTERS | 2008年 / 260卷 / 1-2期

关键词：

field of cancerization; field defect; gastrointestinal cancer; pre-malignant; cancer progression; tumorigenesis;

D O I：

10.1016/j.canlet.2007.11.027

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

A field of defective tissue may represent a pre-malignant stage in progression to many cancers. However, field defects are often overlooked in studies of cancer progression through assuming tissue at some distance from the cancer is normal. We indicate, however, the generality of field defects in gastrointestinal cancers, including cancers of the oropharynx, esophagus, stomach, bile duct, pancreas, small intestine and colon/rectum. Common features of these field defects are reduced apoptosis competence, aberrant proliferation and genomic instability. These features are often associated with high bile acid exposure and may explain the association of dietary-related factors with cancer progression. (C) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：1 / 10

页数：10

共 71 条

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