Synthesis of N-alkyl substituted indolocarbazoles as potent inhibitors of human cytomegalovirus replication

被引：27

作者：

Slater, MJ ^{[1
]}

Baxter, R ^{[1
]}

Bonser, RW ^{[1
]}

Cockerill, S ^{[1
]}

Gohil, K ^{[1
]}

Parry, N ^{[1
]}

Robinson, E ^{[1
]}

Randall, R ^{[1
]}

Yeates, C ^{[1
]}

Snowden, W ^{[1
]}

Walters, A ^{[1
]}

机构：

[1] GlaxoSmihKline, Med Res Ctr, Stevenage SG1 2NY, Herts, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 15期

关键词：

D O I：

10.1016/S0960-894X(01)00352-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and antiviral evaluation of unsymmetrical indolocarbazole derivatives of Arcyriaflavin A, substituted with a range of alkyl groups at the indole nitrogen, is described. Structure-activity relationships in this series against human cytomegalovirus (HCMV) replication in cell culture are reported. Compound 4b was identified as potent inhibitor of HCMV (IC50 = 19 nM), which retained activity against a range of HCMV strains including ganciclovir resistant isolates. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1993 / 1995

页数：3

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