The nucleoskeleton and attached activities

被引:22
作者
Hozak, P [1 ]
机构
[1] UNIV OXFORD,SIR WILLIAM DUNN SCH PATHOL,OXFORD OX1 2JD,ENGLAND
基金
英国惠康基金;
关键词
D O I
10.1006/excr.1996.0370
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
This review briefly summarizes recent results obtained on the nucleoskeleton of HeLa cells. When the nucleoskeleton is observed in HeLa cells after removal of most chromatin using ''physiological'' conditions, four structural elements can be recognized: nuclear lamina, core filaments, diffuse skeleton, and nuclear bodies. After dispersing the nucleolar granular component, two additional structures can be visualized: the intranucleolar skeleton, and the fibrillar centers. The relationship between the nucleoskeleton and nuclear synthetic activities-DNA replication and ribosomal transcription-is discussed. The nucleoskeleton is an important nuclear structure, involved in nuclear compartmentalization and probably critical for replication and transcription. (C) 1996 Academic Press, Inc.
引用
收藏
页码:267 / 271
页数:5
相关论文
共 24 条
[1]   NUCLEAR PROTEIN MATRIX - ASSOCIATION WITH NEWLY SYNTHESIZED DNA [J].
BEREZNEY, R ;
COFFEY, DS .
SCIENCE, 1975, 189 (4199) :291-293
[2]   NUCLEAR-BODIES (NBS) - A NEWLY REDISCOVERED ORGANELLE [J].
BRASCH, K ;
OCHS, RL .
EXPERIMENTAL CELL RESEARCH, 1992, 202 (02) :211-223
[3]   A NEW METHOD OF PREPARING EMBEDMENT-FREE SECTIONS FOR TRANSMISSION ELECTRON-MICROSCOPY - APPLICATIONS TO THE CYTOSKELETAL FRAMEWORK AND OTHER 3-DIMENSIONAL NETWORKS [J].
CAPCO, DG ;
KROCHMALNIC, G ;
PENMAN, S .
JOURNAL OF CELL BIOLOGY, 1984, 98 (05) :1878-1885
[4]  
COOK PR, 1988, J CELL SCI, V90, P1
[5]   LYSP100-associated nuclear domains (LANDs): Description of a new class of subnuclear structures and their relationship to PML nuclear bodies [J].
Dent, AL ;
Yewdell, J ;
PuvionDutilleul, F ;
Koken, MHM ;
deThe, H ;
Staudt, LM .
BLOOD, 1996, 88 (04) :1423-1436
[6]   NONISOTOPIC ULTRASTRUCTURAL MAPPING OF TRANSCRIPTION SITES WITHIN THE NUCLEOLUS [J].
DUNDR, M ;
RASKA, I .
EXPERIMENTAL CELL RESEARCH, 1993, 208 (01) :275-281
[7]   THE NONCHROMATIN SUBSTRUCTURES OF THE NUCLEUS - THE RIBONUCLEOPROTEIN (RNP)-CONTAINING AND RNP-DEPLETED MATRICES ANALYZED BY SEQUENTIAL FRACTIONATION AND RESINLESS SECTION ELECTRON-MICROSCOPY [J].
FEY, EG ;
KROCHMALNIC, G ;
PENMAN, S .
JOURNAL OF CELL BIOLOGY, 1986, 102 (05) :1654-1665
[8]   LOCALIZATION OF HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN IN THE INTERPHASE NUCLEAR MATRIX CORE FILAMENTS AND ON PERICHROMOSOMAL FILAMENTS AT MITOSIS [J].
HE, DC ;
MARTIN, T ;
PENMAN, S .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (17) :7469-7473
[9]  
HERNANDEZVERDUN D, 1983, EUR J CELL BIOL, V31, P360
[10]  
HOZAK P, 1995, J CELL SCI, V108, P635