Antiangiogenic effects of flavonoids and chalcones

被引：198

作者：

Mojzis, J. ^{[1
]}

Varinska, L. ^{[1
]}

Mojzisova, G. ^{[2
]}

Kostova, I. ^{[3
]}

Mirossay, L. ^{[1
]}

机构：

[1] Safarik Univ, Fac Med, Dept Pharmacol, Kosice 04011, Slovakia

[2] Safarik Univ, Fac Med, Dept Expt Med, Kosice 04011, Slovakia

[3] Med Univ, Fac Pharm, Dept Chem, Sofia, Bulgaria

来源：

PHARMACOLOGICAL RESEARCH | 2008年 / 57卷 / 04期

关键词：

tumour angiogenesis; flavonoids; chalcones;

D O I：

10.1016/j.phrs.2008.02.005

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Angiogenesis, the development of new blood vessels from the existing vasculature, is essential in normal developmental processes. Uncontrolled angiogenesis is a major contributor to a number of disease states such as inflammatory disorders, obesity, asthma, diabetes, cirrhosis, multiple sclerosis, endometriosis, AIDS, bacterial infections and autoimmune disease. It is also considered a key step in turnout growth, invasion, and metastasis. Angiogenesis is required for proper nourishment and removal of metabolic wastes from turnout sites. Therefore, modulation of angiogenesis is considered as therapeutic strategies of great importance for human health. Numerous bioactive plant compounds are recently tested for their antiangiogenic potential. Among the most frequently studied are polyphenols present in fruits and vegetables. Plant polyphenols inhibit angiogenesis and metastasis through regulation of multiple signalling pathways. Specifically, flavonoids and chalcones regulate expression of VEGF, matrix metalloproteinases (MMPs), EGFR and inhibit NF kappa B, PI3-K/Akt, ERK1/2 signalling pathways, thereby causing strong antiangiogenic effects. This review focuses on the antiangiogenic properties of flavonoids and chalcones and examines underlying mechanisms. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：259 / 265

页数：7

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