Association between the APOA2 promoter polymorphism and body weight in Mediterranean and Asian populations: replication of a gene-saturated fat interaction

被引：73

作者：

Corella, D. ^{[1
,2
,3
]}

Tai, E. S. ^{[4
]}

Sorli, J. V. ^{[2
,3
]}

Chew, S. K. ^{[5
]}

Coltell, O. ^{[1
,6
]}

Sotos-Prieto, M. ^{[2
,3
]}

Garcia-Rios, A. ^{[3
,7
]}

Estruch, R. ^{[3
,8
]}

Ordovas, J. M. ^{[1
,3
,9
]}

机构：

[1] Tufts Univ, Nutr & Genom Lab, JM USDA Human Nutr Res Ctr Aging, Boston, MA 02111 USA

[2] Univ Valencia, Sch Med, Genet & Mol Epidemiol Unit, Valencia, Spain

[3] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr, Madrid, Spain

[4] Singapore Gen Hosp, Dept Endocrinol, Singapore 0316, Singapore

[5] Minist Hlth, Epidemiol & Dis Control Div, Singapore, Singapore

[6] Univ Jaume 1, Dept Comp Languages & Syst, Castellon de La Plana, Spain

[7] Univ Cordoba, Reina Sofia Univ, Lipids & Atherosclerosis Res Unit, Cordoba, Spain

[8] Hosp Clin Barcelona, Dept Internal Med, Barcelona, Spain

[9] CNIC, Dept Cardiovasc Epidemiol & Populat Genet, Madrid, Spain

来源：

INTERNATIONAL JOURNAL OF OBESITY | 2011年 / 35卷 / 05期

关键词：

gene-diet interaction; insulin resistance; saturated fat; APOA2; APOLIPOPROTEIN-A-II; DIABETES-SUSCEPTIBILITY GENES; GENOME-WIDE SEARCH; INSULIN-RESISTANCE; MASS INDEX; PHYSICAL-ACTIVITY; TRANSGENIC MICE; FTO GENE; CHROMOSOME; 1Q21-Q24; ADULT OBESITY;

D O I：

10.1038/ijo.2010.187

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: The APOA2 gene has been associated with obesity and insulin resistance (IR) in animal and human studies with controversial results. We have reported an APOA2-saturated fat interaction determining body mass index (BMI) and obesity in American populations. This work aims to extend our findings to European and Asian populations. Methods: Cross-sectional study in 4602 subjects from two independent populations: a high-cardiovascular risk Mediterranean population (n = 907 men and women; aged 67 +/- 6 years) and a multiethnic Asian population (n = 2506 Chinese, n = 605 Malays and n = 494 Asian Indians; aged 39 +/- 12 years) participating in a Singapore National Health Survey. Anthropometric, clinical, biochemical, lifestyle and dietary variables were determined. Homeostasis model assessment of insulin resistance was used in Asians. We analyzed gene-diet interactions between the APOA2 = 265T > C polymorphism and saturated fat intake (< or >= 22 g per day) on anthropometric measures and IR. Results: Frequency of CC (homozygous for the minor allele) subjects differed among populations (1-15%). We confirmed a recessive effect of the APOA2 polymorphism and replicated the APOA2-saturated fat interaction on body weight. In Mediterranean individuals, the CC genotype was associated with a 6.8% greater BMI in those consuming a high (P - 0.018), but not a low (P = 0.316) saturated fat diet. Likewise, the CC genotype was significantly associated with higher obesity prevalence in Chinese and Asian Indians only, with a high-saturated fat intake (P = 0.036). We also found a significant APOA2-saturated fat interaction in determining IR in Chinese and Asian Indians (P 0.026). Conclusion: The influence of the APOA2 -265T > C polymorphism on body-weight-related measures was modulated by saturated fat in Mediterranean and Asian populations. International Journal of Obesity (2011) 35, 666-675; doi: 10.1038/ijo.2010.187; published online 26 October 2010

引用

页码：666 / 675

页数：10

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