Retinoic acid induction of ES-cell-derived neurons:: the radial glia connection

被引：53

作者：

Glaser, T

Brüstle, O

机构：

[1] Univ Bonn, Inst Reconstruct Neurobiol, Life & Brain Ctr, D-53105 Bonn, Germany

[2] Hertie Fdn, D-53105 Bonn, Germany

来源：

TRENDS IN NEUROSCIENCES | 2005年 / 28卷 / 08期

关键词：

D O I：

10.1016/j.tins.2005.05.008

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neuronal induction by retinoic acid (RA) is commonly used in embryonic stem (ES) cell differentiation. Two recent papers show that this paradigm induces a population of neurogenic precursors with properties of radial glia. Upon differentiation, RA-treated cells give rise to a defined and developmentally restricted neuronal lineage. This role of RA in cell fate specification provides new perspectives for studying the radial glia-neuron transition and for generating homogenous populations of neurons from ES cells.

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页码：397 / 400

页数：4

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