Tumour cell death induced by the bulk photovoltaic effect of LiNbO3:Fe under visible light irradiation

被引：33

作者：

Blazquez-Castro, Alfonso ^{[1
,2
]}

Stockert, Juan C. ^{[1
]}

Lopez-Arias, Begona ^{[1
]}

Juarranz, Angeles ^{[1
]}

Agullo-Lopez, Fernando ^{[3
]}

Garcia-Cabanes, Angel ^{[4
]}

Carrascosa, Mercedes ^{[4
]}

机构：

[1] Univ Autonoma Madrid, Fac Ciencias, Dept Biol, E-28049 Madrid, Spain

[2] MD Anderson Int Espana, Ctr Oncol, Unidad Citogenet, Madrid 28033, Spain

[3] Univ Autonoma Madrid, Ctr Microanal Mat, E-28049 Madrid, Spain

[4] Univ Autonoma Madrid, Fac Ciencias, Dept Fis Mat, E-28049 Madrid, Spain

来源：

PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES | 2011年 / 10卷 / 06期

关键词：

ELECTROCHEMICAL TREATMENT; PHOTODYNAMIC THERAPY; TRANSPORT; GENERATION; VOLTAGE;

D O I：

10.1039/c0pp00336k

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

This work reports a pioneer application of the bulk photovoltaic effect in the biomedical field. Massive necrotic cell death was induced in human tumour cell cultures grown on a bulk photovoltaic material (iron-doped lithium niobate, LiNbO3:Fe) after irradiation with visible light. Lethal doses (approximate to 100% cell death) were obtained with low-intensity visible light sources (10-100 mW cm(-2) irradiances) and short exposure times of the order of minutes. The wavelength dependence to induce the lethal effect observed is consistent with that corresponding to the bulk photovoltaic effect generation in LiNbO3:Fe. Necrosis also occurred when cultured tumour cells were exposed to LiNbO3:Fe microparticles and visible light.

引用

页码：956 / 963

页数：8

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