Preparation of 2,5-disubstituted oxazoles from N-propargylamides

被引：141

作者：

Arcadi, A

Cacchi, S

Cascia, L

Fabrizi, G

Marinelli, F

机构：

[1] Univ Studi La Sapienza, Dipartimento Studi Chim & Tecnol Sostanze Biologi, I-00185 Rome, Italy

[2] Univ Aquila, Dipartimento Chim Ingn Chim & Mat, Fac Sci, I-67100 Laquila, Italy

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 16期

关键词：

D O I：

10.1021/ol016133m

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] 2,5-Disubstituted oxazoles have been prepared through the reaction of N-propargylamides with aryl iodides in the presence of Pd-2(dba)(3), tri(2-furyl)phosphine, and (NaOBu)-Bu-f. The reaction appears to proceed through a palladium-catalyzed coupling step followed by the in situ cyclization of the resultant coupling product.

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页码：2501 / 2504

页数：4

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