Subcutaneous Interferon-β injections in patients with multiple sclerosis initiate inflammatory skin reactions by local chemokine induction

被引：40

作者：

Buttmann, M

Goebeler, M

Toksoy, A

Schmid, S

Graf, W

Berberich-Siebelt, F

Rieckmann, P

机构：

[1] Univ Wurzburg, Dept Neurol, D-97080 Wurzburg, Germany

[2] Univ Heidelberg, Univ Hosp Mannheim, Dept Dermatol, D-68135 Mannheim, Germany

[3] Univ Wurzburg, Dept Dermatol, D-97080 Wurzburg, Germany

[4] Univ Wurzburg, Dept Mol Pathol, D-97080 Wurzburg, Germany

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2005年 / 168卷 / 1-2期

关键词：

CXC chemokine IP-10; monocyte chemoattractant protein-1; adverse effects; skin; Interferon-beta;

D O I：

10.1016/j.jneuroim.2005.07.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Subcutaneous Interferon-beta (IFN-beta) injections for the treatment of multiple sclerosis (MS) frequently cause inflammatory injection site reactions. To study the role of chemokines we obtained skin biopsies from 7 MS patients 24 h after injection. At the IFN-beta but not at the contralateral placebo injection sites, we observed strong IP-10/CXCL10 and moderate MCP-1/CCL2 expression associated with extensive perivascular, highly CXCR3-positive T cell and macrophage infiltrates. Primary human skin cells displayed a comparable pattern of chemokine induction after stimulation with IFN-beta in vitro. IFN-beta may therefore trigger inflammatory skin reactions through local chemokine induction followed by rapid immune cell extravasation. (C) 2005 Elsevier B.V. All rights reserved.

引用

页码：175 / 182

页数：8

共 42 条

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