Increasing prevalence of toxin A-negative, toxin B-positive isolates of Clostridium difficile in Korea:: Impact on laboratory diagnosis

被引：61

作者：

Kim, Heejung ^{[1
,2
]}

Riley, Thomas V. ^{[3
]}

Kim, Myungsook ^{[1
,2
]}

Kim, Chang Ki ^{[1
,2
]}

Yong, Dongeun ^{[1
,2
]}

Lee, Kyungwon ^{[1
,2
]}

Chong, Yunsop ^{[1
,2
]}

Park, Jong-Woo ^{[4
]}

机构：

[1] Yonsei Univ, Coll Med, Dept Lab Med, Seoul 120752, South Korea

[2] Yonsei Univ, Coll Med, Res Inst Bacterial Resistance, Seoul 120752, South Korea

[3] Univ Western Australia, Perth, WA 6009, Australia

[4] Chungnam Natl Univ, Coll Med, Dept Lab Med, Taejon, South Korea

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2008年 / 46卷 / 03期

关键词：

D O I：

10.1128/JCM.01188-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Of 462 Korean Clostridium difficile isolates, 77.5% were toxin B positive but 21.4% were toxin A negative (A(-)B(+)). The binary toxin gene was detected in nine isolates. A higher fluoroquinolone resistance of A(-)B(+) strains may contribute to the increase of these strains. Toxin A detection alone may underdiagnose C. difficile-associated disease.

引用

页码：1116 / 1117

页数：2

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