Strategies to control the particle size distribution of poly-ε-caprolactone nanoparticles for pharmaceutical applications

被引：194

作者：

Lince, Federica ^{[1
]}

Marchisio, Daniele L. ^{[1
]}

Barresi, Antonello A. ^{[1
]}

机构：

[1] Politecn Torino, Dipartimento Sci Mat & Ingn Chim, I-10129 Turin, Italy

来源：

JOURNAL OF COLLOID AND INTERFACE SCIENCE | 2008年 / 322卷 / 02期

关键词：

nanoparticles; solvent displacement; poly-epsilon-caprolactone; drug delivery; particle size distribution; mixing;

D O I：

10.1016/j.jcis.2008.03.033

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

In this work turbulent precipitation through solvent displacement for the production of poly-epsilon-caprolactone (PCL) nanoparticles is investigated; two different PCL molecular weights have been employed, using acetone and water as solvent and anti-solvent, respectively. The main important thermodynamic and kinetic parameters, such as solubility and interfacial tension of PCL in water-acetone mixtures, are determined and the effect of the process operating conditions on the final particle size distribution is also investigated. Particles produced under different conditions into a Confined Impinging Jets Reactor (CIJR) were characterized by Dynamic Light Scattering, Zeta potential measurements and Scanning Electronic Microscopy. Results clearly show the strong effect of mixing on the particle size distribution and how mixing must be controlled in order to obtain a product with particular characteristics. Eventually the measured thermodynamic and kinetic parameters are used to interpret the obtained experimental data. (C) 2008 Elsevier Inc. All rights reserved.

引用

页码：505 / 515

页数：11

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