Progesterone receptor membrane component 1 -: Many tasks for a versatile protein

被引:89
作者
Loesel, Ralf M.
Besong, Daniela
Peluso, John J. [2 ]
Wehling, Martin [1 ]
机构
[1] Univ Heidelberg, Inst Expt & Klin Pharmakol, D-68167 Mannheim, Germany
[2] Univ CT Hlth Ctr, Dept Cell Biol, Farmington, CT USA
关键词
progesterone; signaling; steroid metabolism; regulation; protein interaction;
D O I
10.1016/j.steroids.2007.12.017
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The protein now called Progesterone Receptor Membrane Component 1 (PGRMC1) has been described independently by many groups in different cellular contexts. As a result it has been given an impressive diversity of names. While this protein was initially described on the basis of a singular property, e.g. expression or steroid binding, its possible physiological roles have only recently been reported. Current evidence supports the perception that PGRMC1 may be involved in sterol metabolism or homeostasis and cell survival. Here, we summarize a few sometimes neglected pieces of evidence from the literature along with unpublished findings on the properties and functions of PGRMC1. (C) 2007 Elsevier Inc. All rights reserved.
引用
收藏
页码:929 / 934
页数:6
相关论文
共 32 条
[1]   Large-scale characterization of HeLa cell nuclear phosphoproteins [J].
Beausoleil, SA ;
Jedrychowski, M ;
Schwartz, D ;
Elias, JE ;
Villén, J ;
Li, JX ;
Cohn, MA ;
Cantley, LC ;
Gygi, SP .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (33) :12130-12135
[2]   Progesterone receptor membrane component 1: An integrative review [J].
Cahill, Michael A. .
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2007, 105 (1-5) :16-36
[3]   IDENTIFICATION OF PROTEIN CONTACT SITES WITHIN THE GLUCOCORTICOID PROGESTIN RESPONSE ELEMENT [J].
CAIRNS, C ;
GUSTAFSSON, JA ;
CARLSTEDTDUKE, J .
MOLECULAR ENDOCRINOLOGY, 1991, 5 (04) :598-604
[4]  
CRAVEN RJ, 2007, J BIOL CHEM, V22, P22
[5]   Overexpression of the cytochrome P450 activator Hr6 (heme-1 domain protein/hman progesterone receptor) in tumors [J].
Crudden, G ;
Loesel, R ;
Craven, RJ .
TUMOR BIOLOGY, 2005, 26 (03) :142-146
[6]   Specific progesterone binding to a membrane protein and related nongenomic effects on Ca2+-fluxes in sperm [J].
Falkenstein, E ;
Heck, M ;
Gerdes, D ;
Grube, D ;
Christ, M ;
Weigel, M ;
Buddhikot, M ;
Meizel, S ;
Wehling, M .
ENDOCRINOLOGY, 1999, 140 (12) :5999-6002
[7]  
Falkenstein E, 1998, CELL MOL BIOL, V44, P571
[8]   Full-length cDNA sequence of a progesterone membrane-binding protein from porcine vascular smooth muscle cells [J].
Falkenstein, E ;
Meyer, C ;
Eisen, C ;
Scriba, PC ;
Wehling, M .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1996, 229 (01) :86-89
[9]   Chemical modification and structural analysis of the progesterone membrane binding protein from porcine liver membranes [J].
Falkenstein, E ;
Eisen, C ;
Schmieding, K ;
Krautkrämer, M ;
Stein, C ;
Lösel, R ;
Wehling, M .
MOLECULAR AND CELLULAR BIOCHEMISTRY, 2001, 218 (1-2) :71-79
[10]  
Gerdes D, 1998, BIOL CHEM, V379, P907