Epoxyalcohol route to hydroxyethylene dipeptide isosteres: a new synthesis of the diaminoalcohol core of HIV-protease inhibitor ABT-538 (Ritonavir)

被引:42
作者
Benedetti, F [1 ]
Norbedo, S [1 ]
机构
[1] Univ Trieste, Dipartimento Sci Chim, I-34127 Trieste, Italy
关键词
D O I
10.1039/b005804l
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A stereoselective synthesis of the diaminoalcohol core of Ritonavir illustrates a novel approach to hydroxyethylene dipeptide isosteres, based on the regioselective reduction of amino acid-derived epoxyalcohols.
引用
收藏
页码:203 / 204
页数:2
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