Unexpected conformational properties of a peptide constrained by an aliphatic link between the i and i+4 positions

被引：5

作者：

McNamara, LMA

Andrews, MJI

Mitzel, F

Siligardi, G

Tabor, AB

机构：

[1] UCL, Christopher Ingold Labs, Dept Chem, London WC1H 0AJ, England

[2] Kings Coll London, Dept Pharm, London SE1 8WA, England

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 08期

基金：

英国工程与自然科学研究理事会;

关键词：

peptides; circular dichroism; conformation; cyclisation;

D O I：

10.1016/S0040-4039(00)02311-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new method for the synthesis of cyclic peptides bearing unnatural aliphatic linkages between the i and i+4 positions results in a peptide with an unexpectedly strong beta -turn propensity. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1591 / 1593

页数：3

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