KSRP, many functions for a single protein

被引：44

作者：

Briata, Paola ^{[1
]}

Chen, Ching-Yi ^{[2
]}

Giovarelli, Matteo ^{[3
,4
]}

Pasero, Michela ^{[3
]}

Trabucchi, Michele ^{[5
,6
]}

Ramos, Andres ^{[7
]}

Gherzi, Roberto ^{[1
]}

机构：

[1] Ist Nazl Ric Canc IST, I-16132 Genoa, Italy

[2] Univ Alabama Birmingham, Dept Biochem & Mol Genet, Birmingham, AL 35294 USA

[3] Ctr Biotecnol, RNA Technol Lab, I-16132 Genoa, Italy

[4] Univ Genoa, I-16132 Genoa, Italy

[5] Univ Calif San Diego, Howard Hughes Med Inst, Dept Med, La Jolla, CA 92093 USA

[6] Univ Calif San Diego, Sch Med, La Jolla, CA 92093 USA

[7] Natl Inst Med Res, MRC, Div Mol Struct, London NW7 1AA, England

来源：

FRONTIERS IN BIOSCIENCE-LANDMARK | 2011年 / 16卷

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

mRNA decay; KH-domain; microRNA; AU-rich elements; Review; MESSENGER-RNA DECAY; AU-RICH ELEMENT; SPLICING REGULATORY PROTEIN; DENDRITIC TARGETING ELEMENT; POSTTRANSCRIPTIONAL REGULATION; BINDING-PROTEIN; BETA-CATENIN; HNRNP A1; PHOSPHORYLATION; STABILITY;

D O I：

10.2741/3821

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

KSRP is a single-strand nucleic acids binding protein that affects RNA fate at multiple levels. KSRP modular structure and its complex pattern of post-translational modifications underpin the interaction with a wide spectrum of RNA target sequences, as well as with other RNA-binding proteins and molecular adaptors. These interactions are important to the regulation of different steps of mRNA metabolism and, in turn, modulate several aspects of cellular proliferation and differentiation. In this review we will discuss in detail KSRP ability to i) promote decay of labile mRNAs interacting with some components of the mRNA decay machinery and ii) favor the maturation of a select group of microRNA precursors.

引用

页码：1787 / 1796

页数：10

共 70 条

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