Strategies for tolerance induction in nonhuman primates

被引：27

作者：

Hamawy, MM ^{[1
]}

Knechtle, SJ ^{[1
]}

机构：

[1] Univ Wisconsin, Ctr Clin Sci H4 784, Dept Surg, Sch Med, Madison, WI 53792 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 1998年 / 10卷 / 05期

关键词：

D O I：

10.1016/S0952-7915(98)80216-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Organ transplants in nonhuman primates provide a model which closely simulates the biological conditions of human organ transplantation, due to similarities between human and primate MHC (class I and II) structure and expression. Several strategies for tolerance induction have been developed in nonhuman primate models. These include targeting the T cell receptor or costimulatory molecules and the generation of mixed chimerism. Tolerance can be reliably induced in several such models, although none with 100% success.

引用

页码：513 / 517

页数：5

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