Identification of an amino acid signature sequence predictive of protein G-inhibitable IgG(3)-binding activity in group-A streptococcal IgG-binding proteins

被引：12

作者：

Pack, TD

Podbielski, A

Boyle, MDP

机构：

[1] MED COLL OHIO,DEPT MICROBIOL,TOLEDO,OH 43699

[2] RHEIN WESTFAL TH AACHEN,INST MED MICROBIOL,AACHEN,GERMANY

来源：

GENE | 1996年 / 171卷 / 01期

关键词：

immunoglobulin-binding protein; streptococcal M protein; Streptococcus pyogenes; multifunctional-binding protein; protein H; IgG-binding domain;

D O I：

10.1016/0378-1119(96)00102-3

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Sequence comparison of six known group-A streptococcal IgG-binding proteins, sharing the common property of protein G-inhibitable IgG(3)-binding-activity, identified a highly conserved 35-amino-acid (aa) sequence (74-100% similarity) within an EQ-rich central conserved core region of each protein. A search of aa sequence databases identified four additional proteins with > 50% similarity to this consensus sequence. All of these proteins demonstrated protein G-inhibitable IgG(3)-binding activity. Taken together, these results identify a signature sequence that predicts the presence of a protein G-inhibitable IgG(3)-binding domain(s) in group-A streptococcal IgG-binding proteins.

引用

收藏

页码：65 / 70

页数：6

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