Nasal scraping in diagnosing ciliary dyskinesia

被引：19

作者：

Caruso, Giuseppi ^{[1
]}

Gelardi, Matteo ^{[3
]}

Passali, Giulio C. ^{[1
]}

de Santi, Maria M. ^{[2
]}

机构：

[1] Univ Siena, Dept Ear Nose & Throat, I-53100 Siena, Italy

[2] Univ Siena, Dept Human Pathol & Oncol, I-53100 Siena, Italy

[3] Univ Bari, Dept Ear Nose & Throat, Bari, Italy

来源：

AMERICAN JOURNAL OF RHINOLOGY | 2007年 / 21卷 / 06期

关键词：

acquired ciliary dyskinesia; cilia; diagnosis; Kartagener's syndrome; mucociliary transport time; nasal scraping; primary ciliary dyskinesia; transmission electron microscope;

D O I：

10.2500/ajr.2007.21.3107

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Background: Primary ciliary dyskinesia (PCD) is a congenital, clinically and ultrastructurally heterogeneous disease caused by abnormal structure and/or function of cilia. Kartagener's syndrome is one subgroup of PCD. Acquired ciliary dyskinesia is frequent, generally being associated with or following respiratory tract infections. Methods: From January 2003 to April 2006, nasal mucociliary transport time was measured in 64 patients and specimens obtained by nasal scraping were examined by transmission electron microscope (TEM). Results: The 64 nasal scrapings led to the diagnosis of 11 (17.2%) cases of PCD and 51 (79.7%) cases of secondary ciliary disorder. In two cases (3.1%) no clear diagnosis was possible. Conclusion: Nasal scraping is an easy, cheap, and efficient tool for detecting ciliary abnormalities by TEM and for distinguishing acquired and congenital modifications.

引用

页码：702 / 705

页数：4

共 20 条

[1]

AFZELIUS B A, 1976, Science (Washington D C), V193, P317

[2]

Afzelius B A, 1979, Int Rev Exp Pathol, V19, P1

[3]

Bertrand B, 2000, Acta Otorhinolaryngol Belg, V54, P309

[4] Incidence of primary ciliary dyskinesia in children with recurrent respiratory diseases [J].

Chapelin, C ;

Coste, A ;

Reinert, P ;

Boucherat, M ;

Millepied, MC ;

Poron, F ;

Escudier, E .

ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY, 1997, 106 (10) :854-858

[5] Nasal ciliary investigations for the diagnosis of primary ciliary dyskinesia in children [J].

Escudier, E ;

Roger, G ;

Coste, A .

ARCHIVES DE PEDIATRIE, 2004, 11 (04) :390-393

[6] Nasal cytology: Description of a hyperchromatic supranuclear stria as a possible marker for the anatomical and functional integrity of the ciliated cell [J].

Gelardi, M ;

Cassano, P ;

Cassano, M ;

Fiorella, ML .

AMERICAN JOURNAL OF RHINOLOGY, 2003, 17 (05) :263-268

[7]

GELARDI M, 2004, ATLAS NASAL CYTOLOGY, P83

[8]

INGELS K J A O, 1991, Rhinology (Utrecht), V29, P17

[9] SITUS INVERSUS TOTALIS AND KARTAGENERS SYNDROME IN A JAPANESE POPULATION [J].

KATSUHAR.K ;

KAWAMOTO, S ;

BELSKY, JL ;

WAKABAYA.T .

CHEST, 1972, 61 (01) :56-&

[10] METHOD FOR IN-VIVO MEASUREMENT OF MUCOCILIARY ACTIVITY IN THE HUMAN NOSE [J].

LINDBERG, S ;

RUNER, T .

ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY, 1994, 103 (07) :558-566

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