The MAP kinase cascades are activated during post-ischemic liver reperfusion

被引：69

作者：

Bendinelli, P ^{[1
]}

Piccoletti, R ^{[1
]}

Maroni, P ^{[1
]}

BernelliZazzera, A ^{[1
]}

机构：

[1] UNIV MILAN,CNR,CTR STUDIO PATOL CELLULARE,IST PATOL GEN,I-20133 MILAN,ITALY

来源：

FEBS LETTERS | 1996年 / 398卷 / 2-3期

关键词：

liver; post-ischemic reperfusion; MAPK cascade; signal transduction;

D O I：

10.1016/S0014-5793(96)01228-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

We have investigated the involvement of MAP kinase cascades in the response of the liver to post-ischemic reperfusion. Both JNKs and ERKs are activated but the duration and magnitude of the increase in their activities appear to be different, JNK activation is more marked but shorter than that of ERKs. The increase observed in the phosphotyrosine content of the 52 kDa She protein, accompanied by an increased amount of co-immunoprecipitated Grb2, and the activation of Raf-1 kinase provide evidence of the involvement of a Ras-Raf-dependent pathway, with a time course that is similar to that of ERK activation. The treatment of rats with IL-1 receptor antagonist modified all of the described effects, suggesting that IL-1 plays a role in the response of the liver to reperfusion.

引用

页码：193 / 197

页数：5

共 38 条

[1]

THE LIVER RESPONSE TO IN-VIVO HEAT-SHOCK INVOLVES THE ACTIVATION OF MAP KINASES AND RAF AND THE TYROSINE PHOSPHORYLATION OF SHC PROTEINS [J].

BENDINELLI, P ;

PICCOLETTI, R ;

MARONI, P ;

BERNELLIZAZZERA, A .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1995, 216 (01) :54-61

[2]

BERNELLI-ZAZZERA A., 1964, EXP MOL PATHOL, V3, P351, DOI 10.1016/0014-4800(64)90007-3

[3]

BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3

[4]

SYNTHESIS OF HEAT-SHOCK PROTEINS IN RAT-LIVER AFTER ISCHEMIA AND HYPERTHERMIA [J].

CAIRO, G ;

BARDELLA, L ;

SCHIAFFONATI, L ;

BERNELLIZAZZERA, A .

HEPATOLOGY, 1985, 5 (03) :357-361

[5]

PARALLEL SIGNAL-PROCESSING AMONG MAMMALIAN MAPKS [J].

CANO, E ;

MAHADEVAN, LC .

TRENDS IN BIOCHEMICAL SCIENCES, 1995, 20 (03) :117-122

[6]

Persistent activation of c-Jun N-terminal kinase 1 (JNK1) in gamma radiation-induced apoptosis [J].

Chen, YR ;

Meyer, CF ;

Tan, TH .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (02) :631-634

[7]

Colletti LM, 1996, HEPATOLOGY, V23, P506

[8]

THE SMALL GTP-BINDING PROTEINS RAC1 AND CDC42 REGULATE THE ACTIVITY OF THE JNK/SAPK SIGNALING PATHWAY [J].

COSO, OA ;

CHIARIELLO, M ;

YU, JC ;

TERAMOTO, H ;

CRESPO, P ;

XU, NG ;

MIKI, T ;

GUTKIND, JS .

CELL, 1995, 81 (07) :1137-1146

[9]

DAVIS RJ, 1993, J BIOL CHEM, V268, P14553

[10]

JNK1 - A PROTEIN-KINASE STIMULATED BY UV-LIGHT AND HA-RAS THAT BINDS AND PHOSPHORYLATES THE C-JUN ACTIVATION DOMAIN [J].

DERIJARD, B ;

HIBI, M ;

WU, IH ;

BARRETT, T ;

SU, B ;

DENG, TL ;

KARIN, M ;

DAVIS, RJ .

CELL, 1994, 76 (06) :1025-1037

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