Coherence resonance: A mechanism for noise induced stable oscillations in gene regulatory networks

被引:3
作者
El-Samad, Hana [1 ]
Khammash, Mustafa [2 ]
机构
[1] Univ Calif San Francisco, Calif Inst Quantitat Biomed, Dept Biochem & Biophys, San Francisco, CA 94143 USA
[2] Univ Calif, Dept Mech Engn, Santa Barbara, CA USA
来源
PROCEEDINGS OF THE 45TH IEEE CONFERENCE ON DECISION AND CONTROL, VOLS 1-14 | 2006年
基金
美国国家科学基金会;
关键词
D O I
10.1109/CDC.2006.377181
中图分类号
TP [自动化技术、计算机技术];
学科分类号
0812 ;
摘要
Gene regulatory networks are permanently affected by various sources of noise. This noise can have detrimental effects as it interferes with robust operation. However, noise can also produce useful effects. These effects have been recently unravelled in a variety of settings in physics and neurobiology. In this work, we report on one such effect occurring in a model of a gene regulatory network. Specifically, we show that noise is responsible for the appearance of coherence resonance in this system and comment on its implications for our understanding of noise in cellular regulation.
引用
收藏
页码:2382 / +
页数:2
相关论文
共 21 条
[1]   Experimental evidence of van der Pol-Fitzhugh-Nagumo dynamics in semiconductor optical amplifiers [J].
Barland, S ;
Piro, O ;
Giudici, M ;
Tredicce, JR ;
Balle, S .
PHYSICAL REVIEW E, 2003, 68 (03) :6
[2]   A model of periodic oscillation for genetic regulatory systems [J].
Chen, LN ;
Aihara, K .
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS I-REGULAR PAPERS, 2002, 49 (10) :1429-1436
[3]  
ELSAMAD H, 2004, THESIS U CALIFORNIA
[4]   ISOLATION OF TIMELESS BY PER PROTEIN-INTERACTION - DEFECTIVE INTERACTION BETWEEN TIMELESS PROTEIN AND LONG-PERIOD MUTANT PER(L) [J].
GEKAKIS, N ;
SAEZ, L ;
DELAHAYEBROWN, AM ;
MYERS, MP ;
SEHGAL, A ;
YOUNG, MW ;
WEITZ, CJ .
SCIENCE, 1995, 270 (5237) :811-815
[5]   GENERAL METHOD FOR NUMERICALLY SIMULATING STOCHASTIC TIME EVOLUTION OF COUPLED CHEMICAL-REACTIONS [J].
GILLESPIE, DT .
JOURNAL OF COMPUTATIONAL PHYSICS, 1976, 22 (04) :403-434
[6]  
GU FG, 2002, NEUROREPRT, V13, P1657
[7]  
HANGGI P, 1990, REV MOD PHYS, V62, P251, DOI 10.1103/RevModPhys.62.251
[8]   PER PROTEIN INTERACTIONS AND TEMPERATURE COMPENSATION OF A CIRCADIAN CLOCK IN DROSOPHILA [J].
HUANG, ZJ ;
CURTIN, KD ;
ROSBASH, M .
SCIENCE, 1995, 267 (5201) :1169-1172
[9]   Neural excitability, spiking and bursting [J].
Izhikevich, EM .
INTERNATIONAL JOURNAL OF BIFURCATION AND CHAOS, 2000, 10 (06) :1171-1266
[10]  
Khalil HK., 1992, NONLINEAR SYSTEMS