The central enzymes of the aspartate family of amino acid biosynthesis

被引：118

作者：

Viola, RE ^{[1
]}

机构：

[1] Univ Toledo, Dept Chem, Toledo, OH 43606 USA

来源：

ACCOUNTS OF CHEMICAL RESEARCH | 2001年 / 34卷 / 05期

关键词：

D O I：

10.1021/ar000057q

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The aspartate pathway is responsible for the biosynthesis of lysine, threonine, isoleucine, and methionine in most plants and micro-organisms. The absence of this pathway in humans and animals makes the central enzymes potential targets for inhibition, with the aim of developing new herbicides and biocides, and also for enhancement, to improve the nutritional value of crops. Our current state of knowledge of these enzymes is reviewed, including recently determined structural information and newly constructed bifunctional fusion enzymes.

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页码：339 / 349

页数：11

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