A genetic association for cigarette smoking behavior

被引:217
作者
Sabol, SZ
Nelson, ML
Fisher, C
Gunzerath, L
Brody, CL
Hu, S
Sirota, LA
Marcus, SE
Greenberg, BD
Lucas, FR
Benjamin, J
Murphy, DL
Hamer, DH
机构
[1] NCI, Biochem Lab, NIH, Bethesda, MD 20892 USA
[2] NIDR, Bethesda, MD 20892 USA
[3] NIMH, Clin Sci Lab, Bethesda, MD 20892 USA
关键词
smoking; SLC6A3; gene; dopamine; personality;
D O I
10.1037/0278-6133.18.1.7
中图分类号
B849 [应用心理学];
学科分类号
040203 ;
摘要
Dopaminergic genes are likely candidates for heritable influences on cigarette smoking. In an accompanying article, Lerman et al. (1999) report associations between allele 9 of a dopamine transporter gene polymorphism (SLC6A3-9) and lack of smoking, late initiation of smoking, and length of quitting attempts. The present investigation extended their study by examining both smoking behavior and personality traits in a diverse population of nonsmokers, current smokers, and former smokers (N = 1,107). A significant association between SLC6A3-9 and smoking status was confirmed and was due to an effect on cessation rather than initiation. The SLC6A3-9 polymorphism was also associated with low scores for novelty seeking, which was the most significant personality correlate of smoking cessation. It is hypothesized that individuals carrying the SLC6A3-9 polymorphism have altered dopamine transmission, which reduces their need for novelty and reward by external stimuli, including cigarettes.
引用
收藏
页码:7 / 13
页数:7
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