Assessing the current role of platelet function testing

被引：22

作者：

Braunwald, Eugene ^{[1
]}

Angiolillo, Dominick ^{[2
]}

Bates, Eric ^{[3
]}

Berger, Peter B. ^{[4
]}

Hatt, Deepak ^{[5
]}

Cannon, Christopher P. ^{[1
]}

Furman, Mark I. ^{[6
]}

Gurbel, Paul ^{[7
]}

Michelson, Alan D. ^{[8
]}

Peterson, Eric ^{[9
]}

Wiviott, Stephen ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, TIMI Study Grp, Div Cardiovasc,Brigham & Womens Hosp,Dept Med, Boston, MA 02115 USA

[2] Univ Florida, Coll Med, Dept Internal Med, Jacksonville, FL USA

[3] Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA

[4] Geisinger Ctr Hlth Res, Danville, PA USA

[5] Cardiovasc Coordinat Ctr, Dept Cardiovasc Med, Cleveland Clin, Cleveland, OH USA

[6] S Shore Hosp, South Weymouth, MA USA

[7] Johns Hopkins Univ, Dept Med, Sinai Hosp, Sch Med, Baltimore, MD USA

[8] Univ Massachusetts, Ctr Platelet Funct Studies, Sch Med, Worcester, MA 01605 USA

[9] Duke Univ, Med Ctr, Duke Clin Res Inst, Durham, NC USA

来源：

CLINICAL CARDIOLOGY | 2008年 / 31卷 / 03期

关键词：

catheterization/diagnostic interventional < cardiac; acute coronary syndromes < ischemic heart disease; platelets; thrombosis/hypercoagulable states;

D O I：

10.1002/clc.20361

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In vitro platelet function tests are commonly applied in research and offer justification for using antiplatelet therapy. However, studies assessing the ability of standardized platelet function tests to predict patients' clinical response to aspirin or clopidogrel have generated contradictory results. At this time, there is no standardized definition for resistance to antiplatelet therapy, and the appropriate treatment of patients who are hyporesponsive to these agents is not known. Although such tests have a role in research, their place in guiding therapy remains to be established, and prospective trials are urgently needed. The ideal platelet function test for clinical practice would be rapid, easy-to-use, inexpensive, and reliable.

引用

页码：I10 / I16

页数：7

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