Hematopoietic Stem Cell Heterogeneity Takes Center Stage

被引：143

作者：

Copley, Michael R. ^{[1
]}

Beer, Philip A. ^{[1
]}

Eaves, Connie J. ^{[1
]}

机构：

[1] British Columbia Canc Agcy, Terry Fox Lab, Vancouver, BC V5Z 1L3, Canada

来源：

CELL STEM CELL | 2012年 / 10卷 / 06期

基金：

加拿大健康研究院;

关键词：

IN-VIVO PROLIFERATION; COLONY-FORMING CELLS; SELF-RENEWAL; BONE-MARROW; DEVELOPMENTAL SWITCH; PROGENITOR CELLS; CLONAL ANALYSIS; GENE-THERAPY; CFU-S; FETAL;

D O I：

10.1016/j.stem.2012.05.006

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

Over the past 10 years, increasing evidence has accumulated that heterogeneity is a feature of hematopoietic stem cell (HSC) proliferation, self-renewal, and differentiation based on examination of these properties at a clonal level. The heterogeneous behavior of HSCs reflects the operation of a complex interplay of intrinsic and extrinsic variables. In this review, we discuss key findings from the last 5 years that reveal new insights into the mechanisms involved.

引用

页码：690 / 697

页数：8

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