Vaccines based on the native HIV Tat protein and on the combination of Tat and the structural HIV protein variant ΔV2 Env

被引：17

作者：

Ensoli, B

Cafaro, A

Caputo, A

Fiorelli, V

Ensoli, F

Gavioli, R

Ferrantelli, F

Cara, A

Titti, F

Magnani, M

机构：

[1] Ist Super Sanita, AIDS Natl Ctr, I-00161 Rome, Italy

[2] Univ Padua, Dept Histol Microbiol & Med Biotechnol, I-35122 Padua, Italy

[3] Univ Ferrara, Dept Biochem & Mol Biol, I-44100 Ferrara, Italy

[4] Univ Urbino, Inst Biol Chem G Fornaini, I-61029 Urbino, Italy

来源：

MICROBES AND INFECTION | 2005年 / 7卷 / 14期

关键词：

Tat protein; Delta V2 Env protein; HIV/AIDS vaccine;

D O I：

10.1016/j.micinf.2005.07.016

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The promising results obtained with the HIV-1 Tat-based vaccines in mice, monkeys and humans, a better understanding of Tat immunomodulatory functions, as well as evidence that vaccination with trimeric V2 loop-deleted HIV-1 Env induces cross-clade neutralizing antibodies led to the rational design of a novel vaccine based on the combination of Tat and V2-deleted Env. (c) 2005 Elsevier SAS. All rights reserved.

引用

页码：1392 / 1399

页数：8

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