Synthesis and characterization of Pluronic® grafted chitosan copolymer as a novel injectable biomaterial

被引：86

作者：

Chung, HJ

Go, DH

Bae, JW

Jung, IK

Lee, JW

Park, KD ^{[1
]}

机构：

[1] Ajou Univ, Dept Mol Sci & Technol, Suwon 443749, South Korea

[2] Korea Inst Sci & Technol Informat, Dept Mat & Component Informat Anal, Seoul 130742, South Korea

来源：

CURRENT APPLIED PHYSICS | 2005年 / 5卷 / 05期

关键词：

thermosensitivity; chitosan; Pluronic((R)); hydrogels; water soluble;

D O I：

10.1016/j.cap.2005.01.015

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Water-soluble thermosensitive chitosan copolymers were prepared by coupling Pluronic (R) onto chitosan using 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC) and N-hydroxysuccinimide (NHS) as coupling agents. The physicochemical properties of the resulting copolymers were characterized and they formed thermally reversible hydrogels, which exhibit a lower critical solution temperature (LCST) at 34 degrees C in aqueous solutions. As a result, chitosan copolymers attest to the usefulness as an injectable material for cell and drug delivery because of their thermally reversible property. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：485 / 488

页数：4

共 10 条

[1] STATIC AND DYNAMIC PROPERTIES OF A (PEO-PPO-PEO) BLOCK COPOLYMER IN AQUEOUS-SOLUTION [J].