Effects of pinealectomy on glucagon responsiveness to hypoglycaemia induced by insulin injections in fed rats

被引：13

作者：

Kosa, E ^{[1
]}

Maurel, D ^{[1
]}

Siaud, P ^{[1
]}

机构：

[1] Fac Med Nord, Lab Interact Fonct Neuroendocrinol, INSERM, U501, F-13916 Marseille 20, France

来源：

EXPERIMENTAL PHYSIOLOGY | 2001年 / 86卷 / 05期

关键词：

D O I：

10.1113/eph8602205

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The glucagon response to insulin-induced hypoglycaemia was tested in rats that had been pinealectomised (Px), pinealectomised and fitted with melatonin implants (Px + MLT), or sham-operated (SO). The glucagon response to hypoglycaemia observed in SO rats (216 +/- 27 pg ml(-1) at baseline versus 397 +/- 35 pg ml(-1) at the hypoglycaemic peak, Mean +/- S.D.) was stronger than that in Px rats (180 +/- 37 pg ml(-1) and 229 +/- 21 pg ml(-1), respectively) and weaker than that in Px + MLT rats (256 +/- 19 pg ml(-1) and 516 +/- 11 pg ml(-1), respectively). Our data indicate that the capacity to release glucagon during insulin-induced hypoglycaemia is altered in pinealectomised rats.

引用

页码：617 / 620

页数：4

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