RNA silencing in Drosophila

被引：49

作者：

Kavi, HH ^{[1
]}

Fernandez, HR ^{[1
]}

Xie, WW ^{[1
]}

Birchler, JA ^{[1
]}

机构：

[1] Univ Missouri, Div Biol Sci, Columbia, MO 65211 USA

来源：

FEBS LETTERS | 2005年 / 579卷 / 26期

关键词：

RNAi; transgene silencing; transposons; heterochromatin; cosuppression; RNA editing;

D O I：

10.1016/j.febslet.2005.08.069

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Knowledge of the role of RNA in affecting gene expression has expanded in the past several years. Small RNAs serve as homology guides to target messenger RNAs for destruction at the post-transcriptional level in the experimental technique known as RNA interference and in the silencing of some transgenes. These small RNAs are also involved in sequence-specific targeting of chromatin modifications for transcriptional silencing of transgenes, transposable elements, heterochromatin and some cases of Polycomb-mediated gene silencing. RNA silencing processes in Drosophila are described. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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收藏

页码：5940 / 5949

页数：10

相关论文

共 96 条

[1] Tolerance for mutations and chemical modifications in a siRNA [J].

Amarzguioui, M ;

Holen, T ;

Babaie, E ;

Prydz, H .

NUCLEIC ACIDS RESEARCH, 2003, 31 (02) :589-595

[2] The small RNA profile during Drosophila melanogaster development [J].

Aravin, AA ;

Lagos-Quintana, M ;

Yalcin, A ;

Zavolan, M ;

Marks, D ;

Snyder, B ;

Gaasterland, T ;

Meyer, J ;

Tuschl, T .

DEVELOPMENTAL CELL, 2003, 5 (02) :337-350

[3] Double-stranded RNA-mediated silencing of genomic tandem repeats and transposable elements in the D-melanogaster germline [J].

Aravin, AA ;

Naumova, NM ;

Tulin, AV ;

Vagin, VV ;

Rozovsky, YM ;

Gvozdev, VA .

CURRENT BIOLOGY, 2001, 11 (13) :1017-1027

[4] AN UNWINDING ACTIVITY THAT COVALENTLY MODIFIES ITS DOUBLE-STRANDED-RNA SUBSTRATE [J].

BASS, BL ;

WEINTRAUB, H .

CELL, 1988, 55 (06) :1089-1098

[5] Role for a bidentate ribonuclease in the initiation step of RNA interference [J].

Bernstein, E ;

Caudy, AA ;

Hammond, SM ;

Hannon, GJ .

NATURE, 2001, 409 (6818) :363-366

[6]

Birchler James A., 2003, P23

[7]

BUCHETON A, 2002, MOBILE DNA, V2, P796

[8] RNase III enzymes and the initiation of gene silencing [J].

Carmell, MA ;

Hannon, GJ .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2004, 11 (03) :214-218

[9] Fragile X-related protein and VIG associate with the RNA interference machinery [J].

Caudy, AA ;

Myers, M ;

Hannon, GJ ;

Hammond, SM .

GENES & DEVELOPMENT, 2002, 16 (19) :2491-2496

[10] Copy number control of a transposable element, the I factor, a LINE-like element in Drosophila [J].

Chaboissier, MC ;

Bucheton, A ;

Finnegan, DJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (20) :11781-11785

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