Deciphering the pathways of life and death

被引：153

作者：

Li, HL ^{[1
]}

Yuan, JY ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 1999年 / 11卷 / 02期

关键词：

D O I：

10.1016/S0955-0674(99)80035-0

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Caspase recruitment and oligomerization mediated by adaptor proteins constitute a basic mechanism of caspase activation, The complex phenotypes of the caspase knockout mice indicate that multiple mechanisms of caspase activation operate in parallel and that death signal transduction pathways are both cell-type and stimulus specific. The BH3-domain-containing pro-apototic members of Bcl-2 family may be one of the critical links between the initial death signals and the central machinery of apoptosis.

引用

页码：261 / 266

页数：6

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