Further studies of the norditerpene (+)-harringtonolide isolated from Cephalotaxus harringtonia var. drupacea:: Absolute configuration, cytotoxic and antifungal activities

被引：69

作者：

Evanno, Laurent

Jossang, Akino

Nguyen-Pouplin, Julie

Delaroche, Diane ^{[2
]}

Herson, Patrick ^{[3
]}

Seuleiman, Mannan ^{[3
]}

Bodo, Bernard

Nay, Bastien ^{[1
]}

机构：

[1] Museum Natl Hist Nat, Lab Chim & Biochim Subst Nat, CNRS, UMR 5154,Dept RDDM, F-75005 Paris, France

[2] Univ Paris 06, Lab Synth Struct & Fonct Mol Bioact, Paris, France

[3] Univ Paris 06, CNRS, Lab Chim Inorgan & Mat Mol, Paris, France

来源：

PLANTA MEDICA | 2008年 / 74卷 / 08期

关键词：

Cephalotaxus harringtonia var. drupacea; Cephalotaxaceae; nor-diterpenes; absolute configuration; X-ray diffraction; biological activities;

D O I：

10.1055/s-2008-1074546

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Harringtonolide (= hainanolide) is a complex polycyclic fused norditerpene isolated from Cephalotaxus harringtonia var. drupacea. In spite of its appealing biological properties - we measured an IC(50) of 43 nM on KB cells and a significant antifungal activity - its absolute configuration has not yet been firmly established. This was done herein using X-ray anomalous scattering after bromination of the tropone ring, unambiguously giving the stereochemistry 5R,6R,7S,13S,14S,15R,16R. Detailed in vitro biological measurements are provided.

引用

页码：870 / 872

页数：3

共 22 条

[1]

Bao G H, 1983, Zhongguo Yi Xue Ke Xue Yuan Xue Bao, V5, P89

[2] DETERMINATION OF THE ABSOLUTE CONFIGURATION OF OPTICALLY ACTIVE COMPOUNDS BY MEANS OF X-RAYS [J].