Multistep One-Pot Synthesis of Enantioenriched Polysubstituted Cyclopenta[b]indoles

被引：126

作者：

Xu, Biao ^{[1
]}

Guo, Zhi-Lei ^{[1
]}

Jin, Wan-Yan ^{[1
]}

Wang, Zhi-Ping ^{[1
]}

Peng, Yun-Gui ^{[1
]}

Guo, Qi-Xiang ^{[1
]}

机构：

[1] Southwest Univ, Educ Minist Key Lab Luminescence & Real Time Anal, Sch Chem & Chem Engn, Chongqing 400715, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 04期

关键词：

alkylations; indoles; multistep reactions; one-pot syntheses; organocatalysis; ALPHA-ALKYLATION; ALDEHYDES; YUEHCHUKENE; INDOLES; FUNCTIONALIZATION; METHODOLOGIES;

D O I：

10.1002/anie.201107308

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Simple steps, complex result: Consecutive organo-catalyzed reactions of 3-indolylmethanol compounds with aldehydes and N-protected indoles lead to the formation of structurally complex cyclopenta[b]indoles (see scheme, Bn=benzyl). These one-pot multistep reactions have a broad substrate scope and give the products in high yields, and with excellent diastereoselectivities and enantioselectivities. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：1059 / 1062

页数：4

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