Canonical and non-canonical autophagy: variations on a common theme of self-eating?

被引：447

作者：

Codogno, Patrice ^{[1
]}

Mehrpour, Maryam ^{[1
]}

Proikas-Cezanne, Tassula ^{[2
]}

机构：

[1] Univ Paris 11, Inst Natl Sante & Rech Med INSERM, F-92296 Chatenay Malabry, France

[2] Univ Tubingen, Interfac Inst Cell Biol, D-72076 Tubingen, Germany

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2012年 / 13卷 / 01期

关键词：

BECLIN 1-INDEPENDENT AUTOPHAGY; CELL-DEATH; LC3; LIPIDATION; CANCER-CELLS; HUMAN WIPI-1; PATHWAY; BIOGENESIS; MATURATION; PROTEINS; MACROAUTOPHAGY;

D O I：

10.1038/nrm3249

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The autophagosome is the central organelle in macroautophagy, a vacuolar lysosomal catabolic pathway that degrades cytoplasmic material to fuel starving cells and eliminates intracellular pathogens. Macroautophagy has important physiological roles during development, ageing and the immune response, and its cytoprotective function is compromised in various diseases. A set of autophagy-related (ATG) proteins is hierarchically recruited to the phagophore, the initial membrane template in the construction of the autophagosome. However, recent findings suggest that macroautophagy can also occur in the absence of some of these key autophagy proteins, through the unconventional biogenesis of canonical autophagosomes. Such alternatives to the evolutionarily conserved scheme might provide additional therapeutic opportunities.

引用

页码：7 / 12

页数：6

共 59 条

[1] Autophagy is an immediate macrophage response to Legionella pneumophila [J].

Amer, AO ;

Swanson, MS .

CELLULAR MICROBIOLOGY, 2005, 7 (06) :765-778

[2] CD40 induces macrophage anti-Toxoplasma gondii activity by triggering autophagy-dependent fusion of pathogen-containing vacuoles and lysosomes [J].

Andrade, Rosa M. ;

Wessendarp, Matthew ;

Gubbels, Marc-Jan ;

Striepen, Boris ;

Subauste, Carlos S. .

JOURNAL OF CLINICAL INVESTIGATION, 2006, 116 (09) :2366-2377

[3] A Role for Autophagic Protein Beclin 1 Early in Lymphocyte Development [J].

Arsov, Ivica ;

Adebayo, Adeola ;

Kucerova-Levisohn, Martina ;

Haye, Joanna ;

MacNeil, Margaret ;

Papavasiliou, F. Nina ;

Yue, Zhenyu ;

Ortiz, Benjamin D. .

JOURNAL OF IMMUNOLOGY, 2011, 186 (04) :2201-2209

[4] Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum [J].

Axe, Elizabeth L. ;

Walker, Simon A. ;

Manifava, Maria ;

Chandra, Priya ;

Roderick, H. Llewelyn ;

Habermann, Anja ;

Griffiths, Gareth ;

Ktistakis, Nicholas T. .

JOURNAL OF CELL BIOLOGY, 2008, 182 (04) :685-701

[5] Network organization of the human autophagy system [J].

Behrends, Christian ;

Sowa, Mathew E. ;

Gygi, Steven P. ;

Harper, J. Wade .

NATURE, 2010, 466 (7302) :68-U84

[6] α-hemolysin is required for the activation of the autophagic pathway in Staphylococcus aureus-infected cells [J].

Belen Mestre, Maria ;

Fader, Claudio M. ;

Sola, Claudia ;

Isabel Colombo, Maria .

AUTOPHAGY, 2010, 6 (01) :110-125

[7] Ammonia-induced autophagy is independent of ULK1/ULK2 kinases [J].

Cheong, Heesun ;

Lindsten, Tullia ;

Wu, Junmin ;

Lu, Chao ;

Thompson, Craig B. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (27) :11121-11126

[8] Phosphoinositides in cell regulation and membrane dynamics [J].

Di Paolo, Gilbert ;

De Camilli, Pietro .

NATURE, 2006, 443 (7112) :651-657

[9] Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2 [J].

Ferguson, Cole J. ;

Lenk, Guy M. ;

Meisler, Miriam H. .

HUMAN MOLECULAR GENETICS, 2009, 18 (24) :4868-4878

[10] Autophagy machinery mediates macroendocytic processing and entotic cell death by targeting single membranes [J].

Florey, Oliver ;

Kim, Sung Eun ;

Sandoval, Cynthia P. ;

Haynes, Cole M. ;

Overholtzer, Michael .

NATURE CELL BIOLOGY, 2011, 13 (11) :1335-U118

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