Novel binding and efficient cellular uptake of guanidine-based peptide nucleic acids (GPNA)

被引：191

作者：

Zhou, P

Wang, MM

Du, L

Fisher, GW

Waggoner, A

Ly, DH

机构：

[1] Carnegie Mellon Univ, Dept Chem, Pittsburgh, PA 15253 USA

[2] Carnegie Mellon Univ, Ctr Light Microscope Imaging & Biotechnol, Pittsburgh, PA 15253 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 23期

关键词：

D O I：

10.1021/ja029665m

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Incorporation of a guanidine functional group into the PNA backbone facilitates cellular uptake of PNA into mammalian cells with efficiency comparable to that of the TAT transduction domain. The modified PNA recognizes and binds to the complementary DNA strand in accordance with Watson-Crick recognition rules. However, unlike polypyrimidine PNA which binds to DNA in 2:1 stoichiometry, the modified PNA binds to complementary DNA in a 1:1 ratio to form a highly stable duplex. Copyright © 2003 American Chemical Society.

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页码：6878 / 6879

页数：2

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