Preliminary evidence that polymorphisms in dopamine-related transcription factors LMX1A, LMX1B and PITX3 are associated with schizophrenia

被引：20

作者：

Bergman, Olle ^{[1
]}

Westberg, Lars

Nilsson, Lars-Goran ^{[2
]}

Adolfsson, Rolf ^{[3
]}

Eriksson, Elias

机构：

[1] Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Dept Pharmacol, SE-40530 Gothenburg, Sweden

[2] Stockholm Univ, Dept Psychol, S-10691 Stockholm, Sweden

[3] Umea Univ, Dept Clin Sci, Div Psychiat, Umea, Sweden

来源：

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY | 2010年 / 34卷 / 06期

基金：

瑞典研究理事会;

关键词：

LMX1A; LMX1B; Neurodevelopment; PITX3; Schizophrenia; CATECHOL-O-METHYLTRANSFERASE; PROSPECTIVE COHORT; NEURONS; GENE; TRANSPORTER; EXPRESSION; CELLS; PSYCHOSIS; VARIANTS; GENOTYPE;

D O I：

10.1016/j.pnpbp.2010.05.032

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The early development of dopaminergic pathways has been attributed importance for the aetiology of schizophrenia. Several transcription factors are involved in the survival and maturation of dopamine neurons, including LMX1A, LMX1B and PITX3. The possibility that polymorphisms in these genes may influence the development and/or the maintenance of dopaminergic neurons prompted us to investigate if five single nucleotide polymorphisms (SNPs) previously linked to Parkinson's disease are associated with this disorder. Preliminary evidence that genetic variation in LMX1A (rs6668493, rs4657411), LMX1B (rs10987386) and PITX3 (rs4919621) may increase the risk of developing schizophrenia is presented. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：1094 / 1097

页数：4

共 43 条

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