The X family portrait: Structural insights into biological functions of X family polymerases

被引：145

作者：

Moon, Andrea F. ^{[1
]}

Garcia-Diaz, Miguel ^{[1
,2
]}

Batra, Vinod K. ^{[1
]}

Beard, William A. ^{[1
]}

Bebenek, Katarzyna ^{[1
,2
]}

Kunkel, Thomas A. ^{[1
,2
]}

Wilson, Samuel H. ^{[1
]}

Pedersen, Lars C. ^{[1
]}

机构：

[1] NIEHS, Struct Biol Lab, NIH, Res Triangle Pk, NC 27709 USA

[2] NIEHS, Mol Genet Lab, NIH, Res Triangle Pk, NC 27709 USA

来源：

DNA REPAIR | 2007年 / 6卷 / 12期

关键词：

family X polymerase; DNA polymerase beta; DNA polymerase lambda; TdT; DNA polymerase mu; gap-filling; misinsertion misalignment; frameshift lesion bypass; template-dependence; template-independence; substrate specificity;

D O I：

10.1016/j.dnarep.2007.05.009

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The mammalian family X DNA polymerases (DNA polymerases beta, lambda, mu, and TdT) contribute to base excision repair and double-strand break repair by virtue of their ability to fill short gaps in DNA. Structural information now exists for all four of these enzymes, making this the first mammalian polymerase family whose structural portrait is complete. Here we consider how distinctive structural features of these enzymes contribute to their biological functions in vivo. Published by Elsevier B.V.

引用

页码：1709 / 1725

页数：17

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