Study on the electrochemical detection of the macrolide antibiotics clarithromycin and roxithromycin in reversed-phase high-performance liquid chromatography

被引:50
作者
Pappa-Louisi, A [1 ]
Papageorgiou, A
Zitrou, A
Sotiropoulos, S
Georgarakis, E
Zougrou, F
机构
[1] Aristotelian Univ Salonika, Dept Chem, Phys Chem Lab, GR-54006 Salonika, Greece
[2] Aristotelian Univ Salonika, Dept Pharm, Sect Pharmaceut & Drug Control, GR-54006 Salonika, Greece
来源
JOURNAL OF CHROMATOGRAPHY B | 2001年 / 755卷 / 1-2期
关键词
clarithromycin; roxithromycin;
D O I
10.1016/S0378-4347(00)00614-9
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
The optimal conditions of the amperometric detection of the macrolide antibiotics clarithromycin and roxithromycin were found by cyclic voltammetric studies and HPLC-electrochemical detection responses obtained in different temperatures (25.5-60 degreesC) and different but almost isoelutropic binary, ternary and quaternary mixtures of aqueous buffer (pH 7), methanol, acetonitrile and isopropanol. These conditions were also proved to be applicable for the quantitative detection of clarithromycin in human plasma using roxithromycin as an internal standard and vice verse. It was demonstrated that increased attention has to be paid to eluent composition and column temperature to ensure sensitive and reproducible electrochemical responses as well as regularly shaped peaks for both macrolides tested. (C) 2001 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:57 / 64
页数:8
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