Increases in the levels of Coxiella burnetti-specific immunoglobulin G1 and G3 antibodies in acute Q fever and chronic Q fever

被引：6

作者：

Capo, C ^{[1
]}

Iorgulescu, I ^{[1
]}

Mutillod, M ^{[1
]}

Mege, JL ^{[1
]}

Raoult, D ^{[1
]}

机构：

[1] Fac Med Marseille, Unite Rickettsies, CNRS, UPRESA 6020, F-13385 Marseille 05, France

来源：

CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY | 1998年 / 5卷 / 06期

关键词：

D O I：

10.1128/CDLI.5.6.814-816.1998

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A detailed analysis of the humoral response to Coxiella burnetii may provide insight into the pathogenesis of Q fever, a zoonosis caused by C. burnetii. The subclasses of C. burnetii-specific antibodies were determined by immunofluorescence in 20 patients with acute Q fever and 20 patients with chronic Q fever. Although immunoglobulin G1 (IgG1) and IgG3 antibodies were found in acute and chronic Q fever, neither IgG2 nor IgG4 was detected. The detection of IgG1 and IgG3 antibodies was nut due to an increase of the IgG1 and IgG3 subclasses. Moreover, IgG1 and IgG3 antibodies were not correlated, suggesting that they may play different roles in Q fever.

引用

页码：814 / 816

页数：3

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